Thomas Shea is a Professor and Director in the Biological Sciences Department at UMass Lowell.

Thomas B. Shea

Professor, Director

College
Kennedy College of Sciences
Department
Biological Sciences, Climate Change Initiative
Phone
978-934-2881
Email
thomas_shea@uml.edu
Links

Expertise

Cell Biology

Research Interests

In my laboratory researchers are examining the roles played by axonal cytoskeletal proteins in nervous system development, and in the etiology of Alzheimer's and other related neurodegenerative diseases. For these studies we use neurons that are maintained in cell culture as well as genetically-modified strains of mice that are at increased risk for developing neurodegenerative conditions analogous to those observed in humans. Our studies indicate that Alzheimer's disease can arise from a combination of genetics, poor diet, and environmental stress, under conditions where no single one of these factors would induce the disease. My research center collaborates with a number of other nationally and internationally recognized laboratories. I am happy to discuss research opportunities in my laboratory with motivated undergraduate and graduate students.

Education

  • Ph.D.: Biology, (1983), Northeastern University, Boston - Boston, Mass.
  • MS: Biology, (1979), University of Massachusetts, Boston - Boston, Mass.
  • BA: Biology, (1974), University of Massachusetts, Boston - Boston, Mass.

Selected Awards and Honors

  • Departmental Teaching Award (2010)
  • Honorary Chair of the annual "Memory Walk," (2006) - Alzheimer's Association, Lowell, MA
  • Excellence in Research Award (1991) - Umass-Lowell, Lowell, MA
  • Joseph. P. Healy Foundation (1991)
  • William F. Milton Fund Award (1991)
  • Charles A. King Trust Fellowship (1987)
  • Sigma Xi, elected to membership (1981)
  • Phi Sigma Society for Biological Research, elected President (Beta Nu Chapter) (1980)
  • Phi Sigma Society for Biological Research, elected to membership (1979) - Phi Sigma Society

Selected Publications

  • Vohnoutka, R.B., Myre, M., Sargent, A, B., Shea, T.B. (2021). Interaction of lysosomes and calpain on neurofilament steady-state levels. Open Neurology 15, BMS-TONEUJ-2021-5
  • Shea, T.B. (2021). Ex vivo neuronal networks display multiple complex behaviors: emergent properties of nearest-neighbor interactions of excitatory and inhibitory neurons. Open Neurology 15, 3-15.
  • Boumil, E.F., Vohnoutka, R.B., Lee, S., Shea, T.B. (2020). Tau interferes with axonal neurite stabilization and cytoskeletal composition independently of its ability to associate with microtubules. Biology Open 9, bio052530.
  • Guaraldi, M., Lee, S., Shea, T.B. (2020). Synaptic Signals from Glutamate-Treated Neurons Induce Aberrant Post-Synaptic Signals in Untreated Neuronal Networks. Open Neurology 14, 59
  • Shea, T.B. (2019). Choline and phosphatidyl choline may maintain cognitive performance by multiple mechanisms. Invited Editorial. Am J Clin Nutr: 110, 1268-1269.
  • Gonzalez, K.E., Eberiel, D., Shea, T.B. (2019). Collaborative mentoring for retaining secondary biology teachers. J. Microbiol.Biol. Educ. 20
  • Shea, T.B. and Remington, R. (2019). Relative efficacy of a nutraceutical formulation on cognitive performance across the adult lifespan and during early cognitive decline. J Alz dis Reports 30, 251-255.
  • Lee, S., Eyer, L., Letournel, F., Boumil, E., Hall, G., Shea, T.B. (2019). Neurofilaments Form Helical, Flexible Bundles During Neuritogenesis in Culture and Mature Axons in Situ. J Neurosci Res 97, 1306-1318
  • Theochares, B., Vohnoutka, R.B., Boumil, E., Shea, T.B. (2019). Beneficial and deleterious impact of nutritional supplementation for inhibition of proliferation of neuroblastoma in culture. Nutrition and Cancer 6, 1-10
  • Shea, T.B., Remington, R. (2018). Spontaneous neuronal signaling is inherently musical and mathematical: insight into the universal human affinity for music. Open Neurology 12, 64-68
  • Shea, T.B., Remington, R.  (2018). Cognitive improvement in healthy older adults can parallel that of younger adults following lifestyle modification: support for cognitive reserve during aging. J Alz dis Reports 2, 201-205
  • Guaraldi, M., Shea, T.B. (2018). A high-fat and high-cholesterol diet induces overt and latent oxidative damage in hippocampus of mice lacking apolipoprotein E. Open Neuro 12, 12-18.
  • Boumil, E., Vohnoutka, R.B., Liu, Y., Lee, S., Shea, T.B. (2018). Omega-3 hastens and omega-6 delays the progression of neuropathology in a murine model of familial ALS. Open Neuro 11, 84-91.
  • Shea, T.B., Remington, R. (2018). Apparent cognitive decline as revealed by an executive function test within a cohort of elderly individuals self-reporting normal cognitive performance. J Alz dis: 61, 913-915
  • Galkina Cleary, E., Cifuentes, M., Shea, T.B., Grinstein, G. (2018). Ozone potentiates cognitive decline in Alzheimer’s disease: a multicenter, retrospective analysis. J Alz dis: 61, 67-78
  • Boumil, E., Vohnoutka, R.B., Lee, S., Pant, H.C., Shea, T.B. (2018). Assembly and turnover of neurofilaments in growing axonal neurites. Biol Open. 7, 1-15.
  • Vohnoutka, R.B., Boumil, E., Liu, Y., Pant, H.C., Shea, T.B. (2017). Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics. Biol Open 6, 1516-1527.
  • Schulz, A., Lee, S., Guaraldi, M., Yanco, H., Shea, T.B. (2017). Robot-embodied neuronal networks as a model for learning. Open Neurology Journal 11, 3-11.
  • Remington, R., Shea, T.B. (2017). Nutritional Supplements and dementia. Clinical Nutrition 2, 613-614.
  • Therrien, M., Vohnoutka, R., Boumil, E., Guaraldi, M., Lee, S., Shea, T.B. (2016). Insufficient Developmental Excitatory Neuronal Activity Fails to Foster Establishment of Normal Levels of Inhibitory Neuronal Activity. International Journal Of Developmental Neuroscience: The Official Journal Of The International Society For Developmental Neuroscience,55 66 - 71.
  • Remington, R., Bechtel, C., Larsen, D., Samar, A., Page, R., Morrell, C., Shea, T.B. (2016). Maintenance of Cognitive Performance and Mood for Individuals with Alzheimer’s Disease Following Consumption of a Nutraceutical Formulation: A One-Year, Open-Label Study. Journal Of Alzheimer’s Disease: JAD,51(4) 991 - 995.
  • Remington, R., Bechtel, C., Larsen, D., Samar, A., Doshanjh, L., Fishman, P., Luo, Y., Smyers, K., Page, R., Morrell, C., Shea, T.B. (2015). A Phase II Randomized Clinical Trial of a Nutritional Formulation for Cognition and Mood in Alzheimers Disease. Journal of Alzheimer’s Disease,45(2) 395-405.
  • Lee, S., Sohal, I.S., Therrien, M.A., Pal, A.K., Bello, D., Shea, T.B. (2015). Additive Impairment of Synaptic Signaling in Cultured Cortical Neurons by Exogenously-Applied Oligomerized Amyloid-ß and Airborne Nanoparticles Generated during Photocopying. Journal of Alzheimer’s disease,47(1) 49-54.
  • Shultz, A., Lee, S., Shea, T.B., Yanco, H. (2015). Biological and Simulated Neuronal Networks Show Similar Competence on a Visual Tracking Task (pp. 261–266).
  • Bechtel, C., Remington, R., Barton, B., Barasauskas, C., Shea, T.B. (2015). Cognitive Testing for Dementia Is Adversely Affected by Administration in a Foreign Location. BMC research notes,8 66.
  • Doulames, V.M., Vilcans, M., Lee, S., Shea, T.B. (2015). Social Interaction Attenuates the Extent of Secondary Neuronal Damage Following Closed Head Injury in Mice. Frontiers in behavioral neuroscience,9 275.
  • Shea, T.B., Remington, R. (2015). Nutritional Supplementation for Alzheimer’s Disease? Current opinion in psychiatry,28(2) 141-147.
  • Taddeo, M., Lee, S., Shea, T.B. (2014). Synergistic Inhibition of Synaptic Signaling in Cortical Cultures by Subcytotoxic Levels of Oligomerized Amyloid Beta and Iron: Allevation by Zinc. Journal of Alzheimer's Disease,41 365-369.
  • Lee, S., Pant, H., Shea, T. (2014). Divergent and Convergent Roles for Kinases and Phosphatases in Neurofilament Dynamics. Journal of Cell Science,127(18) 4064-4077.
  • Lee, S., Zemianek, J.M., Shultz, A., Vo, A., Maron, B.Y., Therrien, M., Courtright, C., Guaraldi, M., Yanco, H., Shea, T.B. (2014). Synaptic Signal Streams Generated by Ex Vivo Neuronal Networks Contain Non-Random, Complex Patterns. International Journal of Developmental Neuroscience : the official journal of the International Society for Developmental Neuroscience,38 184-194.
  • Shultz, A., Lee, S., Shea, T.B., Yanco, H. (2014). Control of a Robot Arm with Artificial and Biological Neural Networks. AAAI Workshop on Artificial Intelligence and Robotics
  • Doulames, V., Lee, S., Shea, T. (2014). Environmental Enrichment and Social Interaction Improve Cognitive Function in Normal Adult Mice. International Journal of Neuroscience,124 369-376.
  • Shea, T., Rogers, E. (2014). Lifetime Requirement of the Methionine Cycle for Neuronal Development and Maintenance. Current Opinion in Psychiatry,27 138-142.
  • Zemianek, J., Lee, S., Shea, T. (2013). Acceleration of Myofiber Formation in Culture by a Digitized Synaptic Signal. Tissue Engineering - Part A,19(23-24) 2693-2702.
  • Zemianek, J., Lee, S., Guaraldi, M., Shea, T. (2013). Critical Role for Inhibitory Neurons in Modulation of Synaptic Signaling in Ex Vivo Neuronal Networks. International Journal of Developmental Neuroscience,31(5) 308-310.
  • Zemianek, J.M., Shultz, A.M., Lee, S., Guaraldi, M., Yanco, H.A., Shea, T.B. (2013). Transient Epileptiform Signaling During Neuronal Network Development: Regulation by External Stimulation and Bimodal Gabaergic Activity. International Journal of Developmental Neuroscience,31(2) 131-137.
  • Lee, S., Zemianek, J., Shea, T. (2013). Rapid, Reversible Impairment of Synaptic Signaling in Cultured Cortical Neurons by Exogenously-Applied Amyloid-β. Journal of Alzheimer’s Disease,35(2) 395-402.
  • Lee, S., Shea, T.B. (2013). Regulation of Tau Proteolysis by Phosphatases. Brain research,1495 30-36.
  • Zemianek, J.M., Lee, S., Guaraldi, M., Shea, T.B. (2012). Accelerated Establishment of Mature Signaling Patterns Following Stimulation of Developing Neuronal Networks: "Learning" Versus "Plasticity". International Journal of Developmental Neuroscience.
  • Lee, S., Shea, T.B. (2012). Caspase-Mediated Truncation of Tau Potentiates Aggregation. International Journal of Alzheimer's Disease, 731063.
  • Lee, S., Lemere, C.A., Frost, J.L., Shea, T.B. (2012). Dietary Supplementation with S-Adenosyl Methionine Delayed Amyloid-beta and Tau Pathology in 3xTg-AD Mice. Journal of Alzheimers Disease,28(2).
  • Lee, S., Doulames, V., Donnelly, M., Levasseaur, J., Shea, T.B. (2012). Environmental Enrichment Can Prevent Cognitive Decline Induced by Dietary Oxidative Challenge. Journal of Alzheimer's Disease,28(3) 497-501.
  • Sunil, N., Lee, S., Shea, T.B. (2012). Interference with Kinesin-Based Anterograde Neurofilament Axonal Transport Increases Neurofilament-Neurofilament Bundling. Cytoskeleton,69(6) 371-379.
  • Shea, T.B., Rogers, E., Remington, R. (2012). Nutrition and Dementia: Are we Asking the Right Questions? Journal of Alzheimers Disease,30(1).
  • Zemianek, J.M., Serra, M., Guaraldi, M., Shea, T.B. (2012). Stimulation with a Low-Amplitude, Digitized Synaptic Signal to Invoke Robust Activity Within Neuronal Networks on Multielectrode Arrays. BioTechniques,52(3) 177-182.
  • Shea, T.B., Lee, S. (2012). The Discontinuous Nature of Neurofilament Transport Accommodates Both Establishment and Repair of the Axonal Neurofilament Array. Cytoskeleton (Hoboken, N.J.).
  • Lee, S., Sunil, N., Shea, T.B. (2011). C-Terminal Neurofilament Phosphorylation Fosters Neurofilament-Neurofilament Associations That Compete with Axonal Transport. Cytoskeleton,68(1) 8-17.
  • Lee, S., Sunil, N., Tejada, J.M., Shea, T.B. (2011). Differential Roles of Kinesin and Dynein in Translocation of Neurofilaments into Axonal Neurites. Journal of cell science,124(7) 1022-1031.
  • Remington, R., Shea, T.B., Bechtel, C.F., Lortie, J.J., Hoffmann, H., Dosanjh, L., Fishman, P., Samar, A. (2011). Efficacy of a Nutriceutical Formulation on Cognitive Performance in Mci and Ad. Gerontologist,51.
  • Shea, T.B., Lee, S. (2011). Neurofilament phosphorylation regulates axonal transport by an indirect mechanism: A merging of opposing hypotheses. Cytoskeleton,68(11) 589-595.
  • Lee, S., Hall, G.F., Shea, T.B. (2011). Potentiation of Tau Aggregation by cdk5 and GSK3. Journal of Alzheimer's Disease,26(2) 355-364.
  • Shea, T.B., Johnson, J., Westervelt, P., Farag, S., McCarty, J., Bashey, A., Isola, L., Baxter-Lowe, L., Kelly, M., Owzar, K., Linker, C. (2011). Reduced-Intensity Allogeneic Transplantation Provides High Event-Free and Overall Survival in Patients with Advanced Indolent B Cell Malignancies: CALGB 109901. Biology of Blood and Marrow Transplantation,17(9) 1395-1403.
  • Chan, A., Ortiz, D., Rogers, E., Shea, T.B. (2011). Supplementation with Apple Juice Can Compensate for Folate Deficiency in a Mouse Model Deficient in Methylene Tetra Hydrofoate Reductase Activity. Journal of Nutrition, Health and Aging,15(3) 221-225.
  • Lortie, J.J., Remington, R., Shea, T.B., Hoffmann, H. (2011). The Wais Digit Span Test: a Sensitive Indicator of Cognitive Decline in Mild Cognitive Impairment. Gerontologist,51.
  • Chan, A., Remington, R., Kotyla, E., Lepore, A., Zemianek, J., Shea, T.B. (2010). A Vitamin/Nutriceutical Formulation Improves Memory and Cognitive Performance in Community-Dwelling Adults Without Dementia. Journal of Nutrition, Health and Aging,14(3) 224-230.
  • Kushkuley, J., Metkar, S., Chan, W.K., Lee, S., Shea, T.B. (2010). Aluminum Induces Neurofilament Aggregation by Stabilizing Cross-Bridging of Phosphorylated C-Terminal Sidearms. Brain research,1322 118-123.
  • Chan, A., Shea, T.B. (2010). Apolipoprotein E3 as a Risk Factor for Alzheimer's Disease Under Conditions of Nutritional Imbalance. Journal of Alzheimers Disease,21(1).
  • Remington, R., Chan, A., Lepore, A., Kotlya, E., Shea, T.B. (2010). Apple Juice Improved Behavioral but Not Cognitive Symptoms in Moderate-To-Late Stage Alzheimer's Disease in an Open-Label Pilot Study. American Journal of Alzheimer's Disease and Other Dementias,25(4) 367-371.
  • Suchy, J., Lee, S., Ahmed, A., Shea, T.B. (2010). Dietary Supplementation with S-Adenosyl Methionine Delays the Onset of Motor Neuron Pathology in a Murine Model of Amyotrophic Lateral Sclerosis. NeuroMolecular Medicine,12(1) 86-97.
  • Serra, M., Guaraldi, M., Shea, T.B. (2010). Inhibitory Neurons Modulate Spontaneous Signaling in Cultured Cortical Neurons: Density-Dependent Regulation of Excitatory Neuronal Signaling. Physical Biology,7(2).
  • Chan, A., Remington, R., Kotyla, E., Lepore, A., Zemianek, J., Shea, T.B. (2009). A Vitamin/Nutriceutical Formulation Improves Memory and Cognitive Performance in Community-Dwelling Adults Without Dementia. Journal of Nutrition, Health and Aging, 1-7.
  • Serra, M., Shea, T.B. (2009). Apple Juice Stimulates Organized Synaptic Activity in Cultured Cortical Neurons. Current Topics in Nutraceutical Research,7(2) 93-96.
  • Kifle, L., Ortiz, D., Shea, T.B. (2009). Deprivation of Folate and b12 Increases Neurodegeneration Beyond That Accompanying Deprivation of Either Vitamin Alone. Journal of Alzheimer's Disease,16(3) 533-540.
  • Chan, A., Rogers, E., Shea, T.B. (2009). Dietary Deficiency in Folate and Vitamin E Under Conditions of Oxidative Stress Increases Phospho-Tau Levels: Potentiation by apoe4 and Alleviation by S-Adenosylmethionine. Journal of Alzheimer's Disease,17(3) 483-487.
  • Suchy, J., Chan, A., Shea, T.B. (2009). Dietary Supplementation with a Combination of -Lipoic Acid, Acetyl-L-Carnitine, Glycerophosphocoline, Docosahexaenoic Acid, and Phosphatidylserine Reduces Oxidative Damage to Murine Brain and Improves Cognitive Performance. Nutrition Research,29(1) 70-74.
  • Chan, A., Shea, T.B. (2009). Dietary Supplementation with Apple Juice Decreases Endogenous Amyloid- Levels in Murine Brain. Journal of Alzheimer's Disease,16(1) 167-171.
  • Chan, A., Paskavitz, J., Remington, R., Rasmussen, S., Shea, T.B. (2009). Efficacy of a Vitamin/Nutriceutical Formulation for Early-Stage Alzheimer's Disease: A 1-Year, Open-Label Pilot Study with an 16-Month Caregiver Extension. American Journal of Alzheimer's Disease and Other Dementias,23(6) 571-585.
  • Remington, R., Chan, A., Paskavitz, J., Shea, T.B. (2009). Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-Stage to Later-Stage Alzheimer's Disease: A Placebo-Controlled Pilot Study. American Journal of Alzheimer's Disease and Other Dementias,24(1) 27-33.
  • Kushkuley, J., Chan, W.K., Lee, S., Eyer, J., Leterrier, J.F., Letournel, F., Shea, T.B. (2009). Neurofilament Cross-Bridging Competes with Kinesin-Dependent Association of Neurofilaments with Microtubules. Journal of cell science,122(19) 3579-3586.
  • Shea, T.B., Lee, S., Kushkuley, J., Dubey, M., Chan, W.K. (2009). Neurofilament Dynamics: A Tug of War by Microtubule Motors. Future Neurology,4(3) 351-362.
  • Remington, R., Chan, A., Tchantchou, F., Ortiz, D., Shea, T.B. (2009). Neuroprotective Effects of Apples on Cognition and Alzheimer's Disease. Agro Food Industry Hi-Tech,20(6).
  • Serra, M., Chan, A., Dubey, M., Shea, T.B. (2008). A Low-Cost Interface for Multi-Electrode Array Data Acquisition Systems. BioTechniques,45(4) 451-456.
  • Tagne, J., Kakumanu, S., Ortiz, D., Shea, T.B., Nicolosi, R.J. (2008). A Nanoemulsion Formulation of Tamoxifen Increases Its Efficacy in a Breast Cancer Cell Line. Molecular Pharmaceutics,5(2).
  • Tchantchou, F., Shea, T.B. (2008). Chapter 3 Folate Deprivation, the Methionine Cycle, and Alzheimer's Disease (Volume 79: pp. 83-97).
  • Chan, A., Tchantchou, F., Graves, V., Rozen, R., Shea, T.B. (2008). Dietary and Genetic Compromise in Folate Availability Reduces Acetylcholine, Cognitive Performance and Increases Aggression: Critical Role of S-Adenosyl Methionine. Journal of Nutrition, Health and Aging,12(4) 252-261.
  • Perry, S., Levasseur, J., Chan, A., Shea, T.B. (2008). Dietary Supplementation with S-Adenosyl Methionine Was Associated with Protracted Reduction of Seizures in a Line of Transgenic Mice. Comparative medicine,58(6) 604-606.
  • Chan, A., Shea, T.B. (2008). Effects of Dietary Supplementation with N-Acetyl Cysteine, Acetyl-L-Carnitine and S-Adenosyl Methionine on Cognitive Performance and Aggression in Normal Mice and Mice Expressing Human apoe4 . NeuroMolecular Medicine,10(1) 46.
  • Chan, A., Paskavitz, J., Remington, R., Rasmussen, S., Shea, T.B. (2008). Efficacy of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease: A 1-year, Open-label Pilot Study With a 16-Month Caregiver Extension. American Journal of Alzheimers Disease and Other Dementias,23(6).
  • Serra, M., Chan, A., Dubey, M., Gilman, V., Shea, T.B. (2008). Erratum: A Low-Cost Interface for Multi-Electrode Array Data Acquisition Systems. BioTechniques,45(6) 607.
  • Serra, M., Chan, A., Dubey, M., Gilman, V., Shea, T.B. (2008). Folate and S-Adenosylmethionine Modulate Synaptic Activity in Cultured Cortical Neurons: Acute Differential Impact on Normal and Apolipoprotein- Deficient Mice. Physical Biology,5(4).
  • Chan, A.Y., Alsaraby, A., Shea, T.B. (2008). Folate Deprivation Increases Tau Phosphorylation by Homocysteine-Induced Calcium Influx and by Inhibition of Phosphatase Activity: Alleviation by S-Adenosyl Methionine. Brain research,1199 133-137.
  • Tchantchou, F., Shea, T.B. (2008). Folate Deprivation, the Methionine Cycle, and Alzheimer's Disease. Folic Acid and Folates,79.
  • Shea, T.B., Chan, A., Remington, R., Lepore, A., Goodrow, E., Paskavitz, J. (2008). P4-345: A Vitamin/Nutriceutical Formulation That Delays Cognitive Decline and Improves Behavioral Symptoms in Alzheimer's Disease. Alzheimer's & Dementia,4(4, Supplement).
  • Shea, T.B., Chan, W.K. (2008). Regulation of Neurofilament Dynamics by Phosphorylation. European Journal of Neuroscience,27(8) 1893-1901.
  • Shea, T.B., Chan, A. (2008). S-Adenosyl Methionine: A Natural Therapeutic Agent Effective Against Multiple Hallmarks and Risk Factors Associated with Alzheimer's Disease. Journal of Alzheimer's Disease,13(1) 67-70.
  • Tchantchou, F., Graves, M., Falcone, D., Shea, T.B. (2008). S-Adenosylmethionine Mediates Glutathione Efficacy by Increasing Glutathione S-Transferase Activity: Implications for S-Adenosyl Methionine as a Neuroprotective Dietary Supplement. Journal of Alzheimer's Disease,14(3) 323-328.
  • Dubey, M., Chaudhury, P., Kabiru, H., Shea, T.B. (2008). Tau Inhibits Anterograde Axonal Transport and Perturbs Stability in Growing Axonal Neurites in Part by Displacing Kinesin Cargo: Neurofilaments Attenuate Tau-Mediated Neurite Instability. Cell motility and the cytoskeleton,65(2) 89-99.
  • Chan, A., Remington, R., Paskavitz, J., Shea, T.B. (2008). The Clock-Drawing Test: Time for a Change? American Journal of Alzheimer's Disease and Other Dementias,23(4) 377-381.
  • Lee, S., Chu, B., Yao, J., Shea, T.B., Hall, G.F. (2008). The Glutamate-Rich Region of the Larger Lamprey Neurofilament Sidearm Is Essential for Proper Neurofilament Architecture. Brain research,1231 1-5.
  • Kim, F., Kotyla, T., Wilson, T., Kifle, L., Panagiotou, T., Gruverman, I., Tagne, J., Shea, T.B., Nicolosi, R. (2007). A Nanoemulsion of an Anti-Oxidant Synergy Formulation Reduces Tumor Growth Rate in Neuroblastoma-Bearing Nude Mice. Journal of neuropathology and experimental neurology,66(5).
  • DeFuria, J., Shea, T.B. (2007). Arsenic Inhibits Neurofilament Transport and Induces Perikaryal Accumulation of Phosphorylated Neurofilaments: Roles of JNK and GSK-3. Brain research,1181(1) 74-82.
  • Lepore, A., Goodrow, E., Chan, A., Shea, T.B. (2007). Cognitive Performance in Normal Seniors Is Enhanced by a Nutraceutical Formulation. Faseb Journal,21(6).
  • Shea, T.B. (2007). Effects of Dietary Supplementation with N-Acetyl Cysteine, Acetyl-L-Carnitine and S-Adenosyl Methionine on Cognitive Performance and Aggression in Normal Mice and Mice Expressing Human ApoE4. NeuroMolecular Medicine,9(3) 264-269.
  • Chan, A., Shea, T.B. (2007). Folate Deprivation Increases Presenilin Expression, Gamma-Secretase Activity, and Abeta Levels in Murine Brain: Potentiation by ApoE Deficiency and Alleviation by Dietary S-Adenosyl Methionine. Journal of neurochemistry,102(3) 753-760.
  • Motil, J., Dubey, M., Chan, W.K., Shea, T.B. (2007). Inhibition of Dynein but Not Kinesin Induces Aberrant Focal Accumulation of Neurofilaments Within Axonal Neurites. Brain research,1164(1) 125-131.
  • Chan, A., Paskavitz, J., Shea, T.B. (2007). P-011: A Novel Vitamin/Nutraceutical Formulation That Delays Cognitive Decline and Improves Mood in Early-Stage Alzheimer S Disease. Alzheimer's & Dementia,3(3, Supplement).
  • Dubey, M., Shea, T.B. (2007). Potentiation of Arsenic Neurotoxicity by Folate Deprivation: Protective Role of S-Adenosyl Methionine. Nutritional Neuroscience,10(5-6) 199-204.
  • Sihag, R.K., Inagaki, M., Yamaguchi, T., Shea, T.B., Pant, H.C. (2007). Role of Phosphorylation on the Structural Dynamics and Function of Types III and IV Intermediate Filaments. Experimental cell research,313(10) 2098-2109.
  • Pandey, M.K., Tyagi, R., Parmar, V.S., Tucci, V.B., Kumar, J., Shea, T.B., Watterson, A.C. (2007). Synthesis and Characterization of Nanocarrier Containing Antioxidant 4-Methylcoumarin. Abstracts of Papers of the American Chemical Society,234.
  • Shea, T.B., Beaty, W.J. (2007). Traffic Jams: Dynamic Models for Neurofilament Accumulation in Motor Neuron Disease. Traffic,8(4) 445-447.
  • Chan, A., Graves, V., Shea, T.B. (2006). Apple Juice Concentrate Maintains Acetylcholine Levels Following Dietary Compromise. Journal of Alzheimer's Disease,9(3) 287-291.
  • Chan, A., Shea, T.B. (2006). Dietary and Genetically-Induced Oxidative Stress Alter Tau Phosphorylation: Influence of Folate and Apolipoprotein E Deficiency. Journal of Alzheimer's Disease,9(4) 399-405.
  • Shea, T.B., Morris, M.C., Evans, D.A., Schneider, J.A., Tangney, C.C., Bienias, J.L., Aggarwal, N.T. (2006). Dietary Folate and Vitamins B-12 and B-6 Not Associated with Incident Alzheimer's Disease. Journal of Alzheimer's Disease,9(4) 435-443.
  • DeFuria, J., Chen, P., Shea, T.B. (2006). Divergent Effects of the MEKK-1/JNK Pathway on NB2a/d1 Differentiation: Some Activity Is Required for Outgrowth and Stabilization of Neurites but Overactivation Inhibits Both Phenomena. Brain research,1123(1) 20-26.
  • Motil, J., Chan, W.K., Dubey, M., Chaudhury, P., Pimenta, A., Chylinski, T.M., Ortiz, D.T., Shea, T.B. (2006). Dynein Mediates Retrograde Neurofilament Transport Within Axons and Anterograde Delivery of NFs from Perikarya into Axons: Regulation by Multiple Phosphorylation Events. Cell motility and the cytoskeleton,63(5) 266-286.
  • Tchantchou, F., Graves, M., Shea, T.B. (2006). Expression and Activity of Methionine Cycle Genes Are Altered Following Folate and Vitamin E Deficiency Under Oxidative Challenge: Modulation by Apolipoprotein E-Deficiency. Nutritional Neuroscience,9(1-2) 17-24.
  • Tchantchou, F., Graves, M.V., Shea, T.B. (2006). Expression and Activity of Methionine Cycle Genes Are Altered Following Folate and Vitamin E Deficiency Under Oxidative Challenge: Modulation by Apolipoprotein E-Deficiency. Nutritional Neuroscience,9(1-2) 17-24.
  • Shea, T.B. (2006). Folate, the Methionine Cycle, and Alzheimer's Disease. Journal of Alzheimer's Disease,9(4) 359-360.
  • Shea, T.B., Chan, A. (2006). Food for Thought: Dietary Influence on Acetylcholine. Journal of Alzheimer's Disease,10(4) 363-364.
  • Mbadugha, B.N., Seo, J., Ji, H., Mart�sek, P., Roman, L.J., Shea, T.B., Li, H., Poulos, T.L., Silverman, R.B. (2006). Hydroxyl-Terminated Peptidomimetic Inhibitors of Neuronal Nitric Oxide Synthase. Bioorganic & medicinal chemistry,14(11) 3681-3690.
  • Chan, A.Y., Graves, V., Rozen, R., Shea, T.B. (2006). P4-357: Dietary and Genetic Compromise in Folate Availability Reduces Acetylcholine and Cognitive Performance: Critical Role of S-Adenosyl Methionine. Alzheimer's & Dementia,2(3, Supplement).
  • Tchantchou, F., Graves, M., Ortiz, D., Chan, A., Rogers, E., Shea, T.B. (2006). S-Adenosyl Methionine: A Connection Between Nutritional and Genetic Risk Factors for Neurodegeneration in Alzheimer's Disease. Journal of Nutrition, Health and Aging,10(6) 541-544.
  • Shea, T.B., Lombardo, N.B. (2006). Selected Abstracts From the "Wellness For Persons With Dementia" Symposium. Journal of Alzheimer's Disease,9(4) 445-448.
  • Chan, A., Shea, T.B. (2006). Supplementation with Apple Juice Attenuates Presenilin-1 Overexpression During Dietary and Genetically-Induced Oxidative Stress. Journal of Alzheimer's Disease,10(4) 353-358.
  • Shea, T.B., Cavallaro, R.A., Fuso, A., D'Anselmi, F., Seminara, L., Scarpa, S. (2006). The Effect of S-Adenosylmethionine on CNS Gene Expression Studied by cDNA Microarray Analysis. Journal of Alzheimer's Disease,9(4) 415-419.
  • Tchantchou, F., Chan, A., Kifle, L., Ortiz, D., Shea, T.B. (2005). Apple Juice Concentrate Prevents Oxidative Damage and Impaired Maze Performance in Aged Mice. Journal of Alzheimer's Disease,8(3) 283-287.
  • Moran, C.M., Donnelly, M., Ortiz, D., Pant, H.C., Mandelkow, E.M., Shea, T.B. (2005). Cdk5 Inhibits Anterograde Axonal Transport of Neurofilaments but Not That of Tau by Inhibition of Mitogen-Activated Protein Kinase Activity. Molecular Brain Research,134(2) 338-344.
  • Dhitavat, S., Ortiz, D., Rogers, E., Rivera, E., Shea, T.B. (2005). Folate, Vitamin E, and Acetyl-L-Carnitine Provide Synergistic Protection Against Oxidative Stress Resulting from Exposure of Human Neuroblastoma Cells to Amyloid-Beta. Brain research,1061(2) 114-117.
  • Watterson, A.C., Parmar, V.S., Kumar, R., Sharma, S.K., Shakil, N.A., Tyagi, R., Sharma, S.K., Samuelson, L.A., Kumar, J., Nicolosi, R., Shea, T.B. (2005). Indo-U.S. Collaborative Studies on Biocatalytic Generation of Novel Molecular Architectures. Pure and Applied Chemistry,77(1) 201-208.
  • Dawn-Linsley, M., Ekinci, F.J., Ortiz, D., Rogers, E., Shea, T.B. (2005). Monitoring Thiobarbituric Acid-Reactive Substances (TBARS) as an Assay for Oxidative Damage in Neuronal Cultures and Central Nervous System. Journal of neuroscience methods,141(2) 219-222.
  • Tchantchou, F., Graves, M., Rogers, E., Ortiz, D., Shea, T.B. (2005). N-Acteyl Cysteine Alleviates Oxidative Damage to Central Nervous System of ApoE-Deficient Mice Following Folate and Vitamin E-Deficiency. Journal of Alzheimers Disease,7(2).
  • Shea, T.B., Ortiz, D., Nicolosi, R.J., Kumar, R., Watterson, A.C. (2005). Nanosphere-Mediated Delivery of Vitamin E Increases Its Efficacy Against Oxidative Stress Resulting from Exposure to Amyloid Beta. Journal of Alzheimer's Disease,7(4) 297-301.
  • Chan, W.K., Yabe, J.T., Pimenta, A.F., Ortiz, D., Shea, T.B. (2005). Neurofilaments Can Undergo Axonal Transport and Cytoskeletal Incorporation in a Discontinuous Manner. Cell motility and the cytoskeleton,62(3) 166-179.
  • Jung, C., Lee, S., Ortiz, D., Zhu, Q., Julien, J.P., Shea, T.B. (2005). The High and Middle Molecular Weight Neurofilament Subunits Regulate the Association of Neurofilaments with Kinesin: Inhibition by Phosphorylation of the High Molecular Weight Subunit. Molecular Brain Research,141(2) 151-155.
  • Rogers, E.J., Milhalik, S., Ortiz, D., Shea, T.B. (2004). Apple Juice Prevents Oxidative Stress and Impaired Cognitive Performance Caused by Genetic and Dietary Deficiencies in Mice. Journal of Nutrition, Health and Aging,8(2) 92-97.
  • Ortiz, D., Shea, T.B. (2004). Apple Juice Prevents Oxidative Stress Induced by Amyloid-Beta in Culture. Journal of Alzheimer's Disease,6(1) 27-30.
  • Shea, T.B., Yabe, J.T., Ortiz, D., Pimenta, A., Loomis, P., Goldman, R.D., Amin, N., Pant, H.C. (2004). Cdk5 Regulates Axonal Transport and Phosphorylation of Neurofilaments in Cultured Neurons. Journal of cell science,117(6) 933-941.
  • Shea, T.B., Zheng, Y.L., Ortiz, D., Pant, H.C. (2004). Cyclin-Dependent Kinase 5 Increases Perikaryal Neurofilament Phosphorylation and Inhibits Neurofilament Axonal Transport in Response to Oxidative Stress. Journal of neuroscience research,76(6) 795-800.
  • Tchantchou, F., Graves, M.V., Ortiz, D., Rogers, E., Shea, T.B. (2004). Dietary Supplementation with 3-Deaza Adenosine, N-Acetyl Cysteine, and S-Adenosyl Methionine Provide Neuroprotection Against Multiple Consequences of Vitamin Deficiency and Oxidative Challenge. Relevance to Age-Related Neurodegeneration. NeuroMolecular Medicine,6(2-3) 93-104.
  • Tchantchou, F., Graves, M., Ortiz, D., Rogers, E., Shea, T.B. (2004). Dietary Supplementation with Apple Juice Concentrate Alleviates the Compensatory Increase in Glutathione Synthase Transcription and Activity That Accompanies Dietary- and Genetically-Induced Oxidative Stress. Journal of Nutrition, Health and Aging,8(6) 492-496.
  • Shea, T.B., Ortiz, D., Rogers, E. (2004). Differential Susceptibility of Transgenic Mice Lacking One or Both Apolipoprotein Alleles to Folate and Vitamin E Deprivation. Journal of Alzheimer's Disease,6(3) 269-273.
  • Tjiattas, L., Ortiz, D.O., Dhivant, S., Mitton, K., Rogers, E., Shea, T.B. (2004). Folate Deficiency and Homocysteine Induce Toxicity in Cultured Dorsal Root Ganglion Neurons via Cytosolic Calcium Accumulation. Aging Cell,3(2) 71-76.
  • Tchantchou, F., Graves, M., Ashline, D., Morin, A., Pimenta, A., Ortiz, D., Rogers, E., Shea, T.B. (2004). Increased Transcription and Activity of Glutathione Synthase in Response to Deficiencies in Folate, Vitamin E, and Apolipoprotein E. Journal of neuroscience research,75(4) 508-515.
  • Tchantchou, F., Graves, M.V., Ortiz, D., Rogers, E., Shea, T.B. (2004). Interaction of Folate Deficiency and Apolipoprotein E Gene Dosage on Cognitive Impairment and Oxidative Damage to Brain Tissue: Compensatory Regulation of Methionine Cycle Genes. Neurobiology of aging,25.
  • Chan, W.K., Dickerson, A., Ortiz, D., Pimenta, A.F., Moran, C.M., Motil, J., Snyder, S.J., Malik, K., Pant, H.C., Shea, T.B. (2004). Mitogen-Activated Protein Kinase Regulates Neurofilament Axonal Transport. Journal of cell science,117(20) 4629-4642.
  • Jung, C., Chylinski, T.M., Pimenta, A., Ortiz, D., Shea, T.B. (2004). Neurofilament Transport Is Dependent on Actin and Myosin. Journal of Neuroscience,24(43) 9486-9496.
  • Tchantchou, F., Graves, M.V., Ortiz, D., Rogers, E., Shea, T.B. (2004). P4-130 Interaction of Folate Deficiency and Apolipoprotein E Gene Dosage on Cognitive Impairment and Oxidative Damage to Brain Tissue: Compensatory Regulation of Methionine Cycle Genes. Neurobiology of aging,25, Supplement 2.
  • Dubey, M., Hoda, S., Chan, W.K., Pimenta, A., Ortiz, D.D., Shea, T.B. (2004). Reexpression of Vimentin in Differentiated Neuroblastoma Cells Enhances Elongation of Axonal Neurites. Journal of neuroscience research,78(2) 245-249.
  • Shea, T.B., Ashline, D., Ortiz, D., Milhalik, S., Rogers, E. (2004). The S-Adenosyl Homocysteine Hydrolase Inhibitor 3-Deaza-Adenosine Prevents Oxidative Damage and Cognitive Impairment Following Folate and Vitamin E Deprivation in a Murine Model of Age-Related, Oxidative Stress-Induced Neurodegeneration. NeuroMolecular Medicine,5(2) 171-180.
  • Shea, T.B., Ortiz, D. (2003). 17 -Estradiol Alleviates Synergistic Oxidative Stress Resulting from Folate Deprivation and Amyloid- Treatment. Journal of Alzheimer's Disease,5(4) 323-327.
  • Hancock, A.L., Nakuci, E., Nicolosi, R.J., Shea, T.B. (2003). An Antioxidant Formulation That Induces Differentiation of Neuroblastoma in Culture. Neuroscience Research Communications,33(1) 73-76.
  • Shea, T.B., Jung, C., Pant, H.C. (2003). Does Neurofilament Phosphorylation Regulate Axonal Transport? Trends in neurosciences,26(8) 397-400.
  • Shea, T.B., Ekinci, F.J., Ortiz, D., Wilson, T.O., Nicolosi, R.J. (2003). Efficacy of Vitamin E, Phosphatidyl Choline and Pyruvate on Abeta Neurotoxicity in Culture. Journal of Nutrition, Health and Aging,7(4) 252-255.
  • Mattson, M.P., Shea, T.B. (2003). Folate and Homocysteine Metabolism in Neural Plasticity and Neurodegenerative Disorders. Trends in neurosciences,26(3).
  • Mihalick, S.M., Ortiz, D., Kumar, R., Rogers, E., Shea, T.B. (2003). Folate and Vitamin E Deficiency Impair Cognitive Performance in Mice Subjected to Oxidative Stress: Differential Impact on Normal Mice and Mice Lacking Apolipoprotein E. NeuroMolecular Medicine,4(3) 197-201.
  • Ho, P.I., Ashline, D., Dhitavat, S., Ortiz, D., Collins, S.C., Shea, T.B., Rogers, E. (2003). Folate Deprivation Induces Neurodegeneration: Roles of Oxidative Stress and Increased Homocysteine. Neurobiology of disease,14(1) 32-42.
  • Chan, W.K., Yabe, J.T., Pimenta, A.F., Ortiz, D., Shea, T.B. (2003). Growth Cones Contain a Dynamic Population of Neurofilament Subunits. Cell motility and the cytoskeleton,54(3) 195-207.
  • Ekinci, F.J., Ortiz, D., Shea, T.B. (2003). Okadaic Acid Mediates Tau Phosphorylation via Sustained Activation of the L-Voltage-Sensitive Calcium Channel. Molecular Brain Research,117(2) 145-151.
  • Shea, T.B., Rogers, E., Ashline, D., Ortiz, D., Sheu, M.S. (2003). Quantification of Antioxidant Activity in Brain Tissue Homogenates Using the 'Total Equivalent Antioxidant Capacity'. Journal of neuroscience methods,125(1-2) 55-58.
  • Yabe, J.T., Chan, W.K., Wang, F.S., Pimenta, A., Ortiz, D.D., Shea, T.B. (2003). Regulation of the Transition From Vimentin to Neurofilaments During Neuronal Differentiation. Cell motility and the cytoskeleton,56(3) 193-205.
  • Dhitavat, S., Ortiz, D., Shea, T.B., Rivera, E.R. (2002). Acetyl-L-Carnitine Protects Against Amyloid-Beta Neurotoxicity: Roles of Oxidative Buffering and ATP Levels. Neurochemical research,27(6) 501-505.
  • Shea, T.B., Rogers, E., Ashline, D., Ortiz, D., Sheu, M.S. (2002). Apolipoprotein E Deficiency Promotes Increased Oxidative Stress and Compensatory Increases in Antioxidants in Brain Tissue. Free Radical Biology and Medicine,33(8) 1115-1120.
  • Dhitavat, S., Ortiz, D., Rivera, E., Shea, T.B. (2002). Divergent and Convergent Oxidative Damage Following Abeta Treatment in Culture. Molecular biology of the cell,13.
  • Shea, T.B., Ekinci, F.J., Ortiz, D., Dawn-Linsley, M., Wilson, T.O., Nicolosi, R.J. (2002). Efficacy of Vitamin E, Phosphatidyl Choline, and Pyruvate on Buffering Neuronal Degeneration and Oxidative Stress in Cultured Cortical Neurons and in Central Nervous Tissue of Apolipoprotein E-Deficient Mice. Free Radical Biology and Medicine,33(2) 276-282.
  • Shea, T.B., Rogers, E. (2002). Folate Quenches Oxidative Damage in Brains of Apolipoprotein E-Deficient Mice: Augmentation by Vitamin E. Molecular Brain Research,108(1-2) 1-6.
  • Shea, T.B., Rogers, E., Auer, J., Berent, R., Eber, B., Seshadri, S., Wolf, P.A. (2002). Homocysteine and Dementia [1] (multiple letters). New England Journal of Medicine,346(25) 2007-2008.
  • Ho, P.I., Ortiz, D., Rogers, E., Shea, T.B. (2002). Multiple Aspects of Homocysteine Neurotoxicity: Glutamate Excitotoxicity, Kinase Hyperactivation and DNA Damage. Journal of neuroscience research,70(5) 694-702.
  • Ho, R., Ortiz, D., Shea, T.B. (2001). Amyloid- Promotes Calcium Influx and Neurodegeneration via Stimulation of L Voltage-Sensitive Calcium Channels Rather Than NMDA Channels in Cultured Neurons. Journal of Alzheimer's Disease,3(5) 479-483.
  • Dhitavat, S., Rivera, E.R., Rogers, E., Shea, T.B. (2001). Differential Efficacy of Lipophilic and Cytosolic Antioxidants on Generation of Reactive Oxygen Species by Amyloid-. Journal of Alzheimer's Disease,3(6) 525-529.
  • Ho, P., Ashline, D., Dhitavat, S., Collins, S., Rogers, E.J., Shea, T.B. (2001). Folate Deprivation Induces Neurodegeneration: Roles of Oxidative Stress and Increased Homocysteine. Molecular biology of the cell,12.
  • Chan, W.K., Chylinski, T.M., Yabe, J.T., Shea, T.B. (2001). Growth Cones Contain a Highly-Dynamic Population of Neurofilament Subunits. Molecular biology of the cell,12.
  • Ho, P.I., Collins, S.C., Dhitavat, S., Ortiz, D., Ashline, D., Rogers, E., Shea, T.B. (2001). Homocysteine Potentiates -Amyloid Neurotoxicity: Role of Oxidative Stress. Journal of neurochemistry,78(2) 249-253.
  • Chylinski, T.M., Shea, T.B. (2001). Kinesin, Dynein and Myosin Mediate Neurofilament Axonal Transport. Molecular biology of the cell,12.
  • Shea, T.B., Flanagan, L.A. (2001). Kinesin, Dynein and Neurofilament Transport. Trends in neurosciences,24(11) 644-648.
  • Yabe, J.T., Chylinski, T., Wang, F.S., Pimenta, A., Kattar, S.D., Linsley, M.D., Chan, W.K., Shea, T.B. (2001). Neurofilaments Consist of Distinct Populations That Can Be Distinguished by C-Terminal Phosphorylation, Bundling, and Axonal Transport Rate in Growing Axonal Neurites. Journal of Neuroscience,21(7) 2195-2205.
  • Yabe, J.T., Wang, F.S., Chylinski, T., Katchmar, T., Shea, T.B. (2001). Selective Accumulation of the High Molecular Weight Neurofilament Subunit Within the Distal Region of Growing Axonal Neurites. Cell motility and the cytoskeleton,50(1) 1-12.
  • Dhitavat, S., Rivera, E., Shea, T.B. (2001). The Acetyl-CoA Precursor, Acetyl-L-Carnitine, Diminishes Amyloid-Beta Neurotoxicity: Role of ATP and Electron Transport. Molecular biology of the cell,12.
  • Yabe, J.T., Chan, W.K., Chylinski, T.M., Lee, S., Pimenta, A.F., Shea, T.B. (2001). The Predominant Form in Which Neurofilament Subunits Undergo Axonal Transport Varies During Axonal Initiation, Elongation, and Maturation. Cell motility and the cytoskeleton,48(1) 61-83.
  • Ekinci, F.J., Linsley, M.D., Shea, T.B. (2000). Amyloid-Induced Calcium Influx Induces Apoptosis in Culture by Oxidative Stress Rather Than Tau Phosphorylation. Molecular Brain Research,76(2) 389-395.
  • Ekinci, F.J., Shea, T.B. (2000). Amyloid-Induced Tau Phosphorylation Does Not Correlate with Degeneration in Cultured Neurons. Journal of Alzheimer's Disease,2(1) 7-15.
  • Ma, D., Himes, B.T., Shea, T.B., Fischer, I. (2000). Axonal Transport of Microtubule-Associated Protein 1B (MAP1B) in the Sciatic Nerve of Adult Rat: Distinct Transport Rates of Different Isoforms. Journal of Neuroscience,20(6) 2112-2120.
  • Ekinci, F.J., Linsley, M.D., Shea, T.B. (2000). Beta-Amyloid-Induced Calcium Influx Induces Apoptosis in Culture by Oxidative Stress Rather Than Tau Phosphorylation. Brain research.Molecular brain research,76(2).
  • Jung, C., Yabe, J.T., Shea, T.B. (2000). C-Terminal Phosphorylation of the High Molecular Weight Neurofilament Subunit Correlates with Decreased Neurofilament Axonal Transport Velocity. Brain research,856(1-2) 12-19.
  • Jung, C., Yabe, J.T., Lee, S., Shea, T.B. (2000). Hypophosphorylated Neurofilament Subunits Undergo Axonal Transport More Rapidly Than Move Extensively Phosphorylated Subunits in Situ. Cell motility and the cytoskeleton,47(2).
  • Shea, T.B. (2000). Microtubule Motors, Phosphorylation and Axonal Transport of Neurofilaments. Brain Cell Biology,29(11-12) 873-887.
  • Chan, W.K., Chylinski, T.M., Yabe, J.T., Pimenta, A.F., Shea, T.B. (2000). Mitogen Activated Protein Kinase Influences Neurofilament Axonal Transport. Molecular biology of the cell,11.
  • Shea, T.B. (2000). Modulation of Calpain-Mediated Protein Kinase C Activation Within Intact Cells. Methods in molecular biology (Clifton, N.J.),144.
  • Chylinski, T., Yabe, J.T., Chan, W.K., Lee, S.M., Pimenta, A.F., Shea, T.B. (2000). Neurofilaments Can Undergo Axonal Transport in Multiple Forms. Molecular biology of the cell,11.
  • Shea, T.B., Yabe, J. (2000). Occam's Razor Slices Through the Mysteries of Neurofilament Axonal Transport: Can It Really Be so Simple? Traffic,1(6) 522-523.
  • Yabe, J.T., Jung, C., Chan, W.K., Shea, T.B. (2000). Phospho-Dependent Association of Neurofilament Proteins with Kinesin in Situ. Cell motility and the cytoskeleton,45(4) 249-262.
  • Ekinci, F.J., Shea, T.B. (2000). Phosphorylation of Tau Alters Its Association with the Plasma Membrane. Cellular and molecular neurobiology,20(4) 497-508.
  • Jung, C., Yabe, J.T., Lee, S., Shea, T.B. (2000). Stochastic Simulation of Processive and Oscillatory Sliding Using a Two-Headed Model for Axonemal Dynein. Cell motility and the cytoskeleton,47(2) 108-119.
  • Yabe, J.T., Chan, W.K., Chylinski, T.M., Lee, S., Pimenta, A.F., Shea, T.B. (2000). The Predominant Form in Which Neurofilament Subunits Undergo Axonal Transport Varies During Axonal Initiation, Elongation, and Maturation. Cell motility and the cytoskeleton,48(1) 61-83.
  • Ekinci, F.J., Malik, K.U., Shea, T.B. (1999). Activation of the L Voltage-Sensitive Calcium Channel by Mitogen- Activated Protein (MAP) Kinase Following Exposure of Neuronal Cells to - Amyloid. MAP Kinase Mediates -Amyloid-Induced Neurodegeneration. Journal of Biological Chemistry,274(42) 30322-30327.
  • Ekinci, F.J., Linsley, M.D., Shea, T.B. (1999). Beta-Amyloid-Induced Calcium Influx Induces Neurodegeneration in Culture by Oxidative Stress rather than Tau Phosphorylation. Molecular biology of the cell,10.
  • Shea, T.B., Ekinci, F.J. (1999). Biphasic Effect of Calcium Influx on Tau Phosphorylation: Involvement of Calcium-Dependent Phosphatase and Kinase Activities. Journal of Alzheimer's Disease,1(6) 353-360.
  • Ekinci, F.J., Shea, T.B. (1999). Free PKC Catalytic Subunits (PKM) Phosphorylate Tau via a Pathway Distinct from That Utilized by Intact PKC. Brain research,850(1-2) 207-216.
  • Ekinci, F.J., Shea, T.B. (1999). Hyperactivation of Mitogen-Activated Protein Kinase Increases Phospho- Tau Immunoreactivity Within Human Neuroblastoma: Additive and Synergistic Influence of Alteration of Additional Kinase Activities. Cellular and molecular neurobiology,19(2) 249-260.
  • Yabe, J.T., Pimenta, A., Shea, T.B. (1999). Kinesin-Mediated Transport of Neurofilament Protein Oligomers in Growing Axons. Journal of cell science,112(21) 3799-3814.
  • Shea, T.B., Beermann, M.L. (1999). Neuronal Intermediate Filament Protein -Internexin Facilitates Axonal Neurite Elongation in Neuroblastoma Cells. Cell motility and the cytoskeleton,43(4) 322-333.
  • Shea, T.B., Yabe, J.T., Wang, F.S. (1999). Non-Uniform Transport and Distribution of Neurofilament Subunits in Growing Axonal Neurites. Molecular biology of the cell,10.
  • Jung, C., Shea, T.B. (1999). Regulation of Neurofilament Axonal Transport by Phosphorylation in Optic Axons in Situ. Cell motility and the cytoskeleton,42(3) 230-240.
  • Shea, T.B. (1999). Selective Stabilization of Microtubules Within the Proximal Region of Developing Axonal Neurites. Brain research bulletin,48(3) 255-261.
  • Shea, T.B., Cressman, C.M. (1999). The Order of Exposure of Tau to Signal Transduction Kinases Alters the Generation of 'AD-Like' Phosphoepitopes. Cellular and molecular neurobiology,19(2) 223-233.
  • Shea, T.B., Dergay, A.N., Ekinci, F.J. (1998). -Amyloid induced hyperphosphorylation of tau in human neuroblastoma cells involves MAP kinase. Neuroscience Research Communications,22(1) 45-49.
  • Shea, T.B., Cressman, C.M. (1998). A 26-30 kDa developmentally-regulated tau isoform localized within nuclei of mitotic human neuroblastoma cells. International Journal of Developmental Neuroscience,16(1) 41-48.
  • Shea, T.B., Dergay, A.N., Ekinci, F.J. (1998). Amyloid Induced Hyperphosphorylation of Tau in Human Neuroblastoma Cells Involves MAP Kinase. Neuroscience Research Communications,22(1) 45-49.
  • Shea, T.B., Dergay, A.N., Ekinci, F.J. (1998). Beta-Amyloid Induced Hyperphosphorylation of Tau in Human Neuroblastoma Cells Involves MAP Kinase. Neuroscience Research Communications,22(1).
  • Shea, T.B., Didier, M. (1998). Biphasic Effects of Phosphatase Inhibiton on Accumulation of Tau Phospho-Isoforms in Cultured Cerebellar Neurons. Neuroscience Research Communications,22(1) 39-44.
  • Ekinci, F.J., Shea, T.B. (1998). Calcium Influx Following Beta-Amyloid Exposure Is Mediated by Mitogen-Activated Protein (MAP) Kinase. Molecular biology of the cell,9.
  • Boyce, J.J., Shea, T.B. (1998). Divergent Influences of Protein Kinase C Isoforms on Intracellular Levels of Phosphorylated and Non-Phosphorylated Tau Immunoreactivity. Neuroscience Research Communications,22(1) 51-57.
  • Shea, T.B., Jung, C., Yabe, J., Ma, D., Fischer, I. (1998). Extensive Phosphorylation and Axonal Transport of Triton-Soluble Neurofilament Subunits. Sub-cellular biochemistry,31 527-561.
  • Surprenant, M.J., Shea, T.B. (1998). Induction of Morphological Differentiation of Neuroblastoma Cells by a Mitotic Inhibitor: Neuritogenesis Is a Default Pathway Invoked by Developmental Withdrawal of Neuroblasts from the Mitotic Cycle. Neuroscience Research Communications,22(1) 59-62.
  • Jung, C., Yabe, J., Wang, F.S., Shea, T.B. (1998). Neurofilament Subunits Can Undergo Axonal Transport Without Incorporation into Triton-Insoluble Structures. Cell motility and the cytoskeleton,40(1) 44-58.
  • Yabe, J.T., Jung, C., Shea, T.B. (1998). Regulation of Neurofilament Axonal Transport by Phosphorylation in Optic Axons in Situ: Involvement of the Microtubule Motor Protein Kinesin. Molecular biology of the cell,9.
  • Tupper, C.L., Shea, T.B. (1998). Transforming Growth Factor 2 Can Exert Protection Towards and Exacerbation of -Amyloid Toxicity Depending upon Growth Factor Concentration and Length of Exposure. Neuroscience Research Communications,22(2) 83-89.
  • Pundreddy, S., Shea, T.B. (1997). AD-like tau phosphorylation in human neuroblastoma cells following PKC hyperactivation is mediated by MAP kinase. Neuroscience Research Communications,21(3) 173-177.
  • Shea, T.B., Wheeler, E., Jung, C. (1997). Aluminum inhibits neurofilament assembly, cytoskeletal incorporation, and axonal transport: Dynamic nature of aluminum-induced perikaryal neurofilament accumulations as revealed by subunit turnover. Molecular and Chemical Neuropathology,32(1-3) 17-39.
  • Shea, T.B., Prabhakar, S., Ekinci, F.J. (1997). Amyloid and Ionophore a23187 Evoke Tau Hyperphosphorylation by Distinct Intracellular Pathways: Differential Involvement of the Calpain/Protein Kinase C System. Journal of neuroscience research,49(6) 759-768.
  • Jung, C., Wheeler, E., Dahl, D., Shea, T.B. (1997). Axonally-Transported Neurofilament Proteins Exist in Multiple Solubility States in Mouse Optic Pathway and NB2A/D1 Cells. Journal of neurochemistry,69.
  • Shea, T.B., Prabhakar, S., Ekinci, F.J. (1997). Beta-Amyloid and Ionophore A23187 Evoke Tau Hyperphosphorylation by Distinct Intracellular Pathways: Differential Involvement of the Calpain Protein Kinase C System. Journal of neuroscience research,49(6).
  • Tupper, C., Pundreddy, S., Prabhakar, S., Chang, M., Shea, T.B. (1997). Beta-Amyloid and Ionophore-Mediated Calcium Influx Evoke Tau Hyperphosphorylation by Distinct and Common Intracellular Pathways: Differential Involvement of the Calpain Protein Kinase C System. Journal of neurochemistry,69.
  • Grynspan, F., Griffin, W.B., Mohan, P.S., Shea, T.B., Nixon, R.A. (1997). Calpains and Calpastatin in SH-SY5Y Neuroblastoma Cells During Retinoic Acid-Induced Differentiation and Neurite Outgrowth: Comparison with the Human Brain Calpain System. Journal of neuroscience research,48(3) 181-191.
  • Shea, T.B. (1997). Creation of a ''Virtual'' Journal Club Using a Threaded Internet Newsgroup. Molecular biology of the cell,8.
  • Yabe, J., Katchmar, T., Shea, T.B. (1997). Non-Uniform Distribution of Soluble and Insoluble Neurofilament Immunoreactivity in Growing Axons. Molecular biology of the cell,8.
  • Shea, T.B. (1997). Phospholipids Alter Tau Conformation, Phosphorylation, Proteolysis, and Association with Microtubules: Implication for Tau Function Under Normal and Degenerative Conditions. Journal of neuroscience research,50(1) 114-122.
  • Boyce, J.J., Shea, T.B. (1997). Phosphorylation Events Mediated by Protein Kinase C and Participate in Regulation of Tau Steady-State Levels and Generation of Certain 'Alzheimer-Like' Phospho-Epitopes. International Journal of Developmental Neuroscience,15(3) 295-307.
  • Shea, T.B., Fischer, I. (1997). Phosphorylation of High Molecular Weight Tau Within Neuroblastoma and Under Cell-Free Conditions Retards Its Electrophoretic Migration and Generates 'AD-Like' Immunoreactivity. Neuroscience Research Communications,21(3) 195-201.
  • Jung, C., Shea, T.B. (1997). Regional Decline in Neurofilament Axonal Transport: Correlation with NF-H Phosphorylation. Molecular biology of the cell,8.
  • Shea, T.B. (1997). Restriction of M-Calcium-Requiring Calpain Activation to the Plasma Membrane in Human Neuroblastoma Cells: Evidence for Regionalized Influence of a Calpain Activator Protein. Journal of neuroscience research,48(6) 543-550.
  • Ekinci, F.J., Shea, T.B. (1997). Selective Activation by Bryostatin-1 Demonstrates Unique Roles for PKC in Neurite Extension and Tau Phosphorylation. International Journal of Developmental Neuroscience,15(7) 867-874.
  • Shea, T.B., Yabe, J., Jung, C. (1997). Soluble Neurofilament Subunits in Axons. Molecular biology of the cell,8.
  • Ekinci, F., Pundreddy, S., Wheeler, E., Shea, T.B. (1997). Tau Phosphorylation Is Regulated by Divergent and Convergent Signal Transduction Pathways. Journal of neurochemistry,69.
  • Shea, T.B., Dahl, D.C., Nixon, R.A., Fischer, I. (1997). Triton-Soluble Phosphovariants of the Heavy Neurofilament Subunit in Developing and Mature Mouse Central Nervous System. Journal of neuroscience research,48(6) 515-523.
  • Shea, T.B., Husain, T. (1996). Astroglial-Secreted Factors Induce the Elaboration of Unstable Axonal Neurites by NB2a/d1 Neuroblastoma Cells: Correlation with Deficiencies in MAP1b and Phospho-Isoforms of the High Molecular Weight Neurofilament Subunit. Neuroscience Research Communications,18(1) 63-70.
  • Shea, T.B., Spencer, M.J., Beermann, M.L., Cressman, C.M., Nixon, R.A. (1996). Calcium Influx into Human Neuroblastoma Cells Induces ALZ-50 Immunoreactivity: Involvement of Calpain-Mediated Hydrolysis of Protein Kinase C. Journal of neurochemistry,66(4) 1539-1549.
  • Ekinci, F.J., Boyce, J.B., Shea, T.B. (1996). Differential Effects of Bryostatin and Phorbol Esters on Neuroblastoma Cells: Unique Role of Protein Kinase C Epsilon. Journal of neurochemistry,66.
  • Shea, T.B. (1996). Induction of Lysosomal Abnormalities and Tau Hyperphosphorylation in Human Neuroblastoma Cells by Colchicine and Okadaic Acid: Evidence That Microtubule Disruption Contributes to Alzheimer Neurodegeneration. Neuroscience Research Communications,19(1) 27-36.
  • Shea, T.B., Fischer, I. (1996). Phosphatase Inhibition in Human Neuroblastoma Cells Alters Tau Antigenicity and Renders It Incompetent to Associate with Exogenous Microtubules. FEBS letters,380(1-2) 63-67.
  • Shea, T.B., Cressman, C.M., Fischer, I. (1996). Preferential Translocation of HMW Tau Isoforms into Newly-Elaborated Neurites in Human Neuroblastoma. Journal of neurochemistry,66.
  • Boyce, J.J., Ennulat, D.J., Leli, U., Shea, T.B. (1996). Regulation of Neuronal Differentiation by the and Isoforms of Protein Kinase C. Neuroscience Research Communications,18(3) 195-201.
  • Boyne, L.J., Fischer, I., Shea, T.B. (1996). Role of Vimentin in Early Stages of Neuritogenesis in Cultured Hippocampal Neurons. International Journal of Developmental Neuroscience,14(6) 739-748.
  • Cressman, C.M., Boyce, J.B., Wheeler, E., Chang, M., Shea, T.B. (1996). Site-Specific Synergism Between PKC and MAP Kinase in Tau Hyperphosphorylation in Intact SH-SY-5Y Human Neuroblastoma. Journal of neurochemistry,66.
  • Sihag, R.K., Shea, T.B., Wang, F.S. (1996). Spectrin-Actin Interaction Is Required for Neurite Extension in NB 2a/Dl Neuroblastoma Cells. Journal of neuroscience research,44(5) 430-437.
  • Shea, T.B. (1996). The Influence of Surface Protease Activity on Neuritogenesis and Neurite Retraction Is Dependent upon Mode of Neurite Induction: Inhibition of Thrombin-Mediated Surface Protease Activity Is Cruicial for Neurite Outgrowth but Not for Maintenance of Existing Neurites. Neuroscience Research Communications,19(1) 57-60.
  • Cressman, C.M., Mercken, M.M., Shea, T.B. (1995). Alteration in Tau Antigenicity and Electrophoretic Migration by PKC Under Cell-Free Conditions. Neuroscience Research Communications,17(2) 61-64.
  • Shea, T.B., Beermann, M.L., Nixon, R.A. (1995). Aluminum Treatment of Intact Neuroblastoma Cells Alters Neurofilament Subunit Phosphorylation, Solubility, and Proteolysis. Molecular and Chemical Neuropathology,26(1) 1-14.
  • Shea, T.B. (1995). Calcium Modulates Aluminum Neurotoxicity and Interaction with Neurofilaments. Molecular and Chemical Neuropathology,24(2-3) 151-163.
  • Shea, T.B. (1995). Differential Synthesis and Cytoskeletal Deposition of Neurofilament Subunits Before and During Axonal Outgrowth in NB2a/d1 Cells: Evidence That Segregation of Phosphorylated Subunits Within the Axonal Cytoskeleton Involves Selective Deposition. Journal of neuroscience research,40(2) 225-232.
  • Shea, T.B., Cressman, C.M., Spencer, M.J., Beermann, M.L., Nixon, R.A. (1995). Enhancement of Neurite Outgrowth Following Calpain Inhibition Is Mediated by Protein Kinase C. Journal of neurochemistry,65(2) 517-527.
  • Cressman, C.M., Shea, T.B. (1995). Hyperphosphorylation of Tau and Filopodial Retraction Following Microinjection of Protein Kinase C Catalytic Subunits. Journal of neuroscience research,42(5) 648-656.
  • Shea, T.B., Husain, T. (1995). Inhibition of Proteolysis Enhances Aluminum-Induced Perikaryal Neurofilament Accumulation but Does Not Enhance Tau Accumulation. Molecular and Chemical Neuropathology,26(3) 195-212.
  • Shea, T.B., Wheeler, E., Wang, F.S. (1995). Neurofilament Translocation into Axonal Neurites is Distinct from Incorporation into the Cytoskeleton. Molecular biology of the cell,6.
  • Lang, D., Beermann, M.L., Hauser, G., Cressman, C.M., Shea, T.B. (1995). Phospholipids Inhibit Proteolysis of Protein Kinase C Alpha by mM Calcium-Requiring Calpain. Neurochemical research,20(11).
  • Boyce, J.J., Ennulat, D.J., Neve, R., Shea, T.B. (1995). Pkc-Epsilon and Pkc-Alpha Regulate Tau Levels and Phosphorylation State. Molecular biology of the cell,6.
  • Cressman, C.M., Mohan, P.S., Nixon, R.A., Shea, T.B. (1995). Proteolysis of Protein Kinase C: mM and M Calcium-Requiring Calpains Have Different Abilities to Generate, and Degrade the Free Catalytic Subunit, Protein Kinase M. FEBS letters,367(3) 223-227.
  • Shea, T.B., Beermann, M.L., Wang, F.S. (1995). Relative Susceptibility of Cytoskeleton-Associated and Soluble Neurofilament Subunits to Aluminum Exposure in Intact-Cells - a Possible Mechanism for Reduction of Neurofilament Axonal-Transport during Aluminum Neurotoxicity. Molecular and Chemical Neuropathology,24(2-3).
  • Shea, T.B. (1995). Role of Glial-Derived Nexin in Neuronal Differentiation and in Acute Brain Injury and Potential Involvement in Exacerbation of Neurodegeneration in Alzheimer's Disease. Brain Research Reviews,20(2) 171-184.
  • Sihag, R.K., Shea, T.B., Wang, F.S. (1995). Spectrin-Actin Interaction is Required for Neurite Extension in Nb 2a/d1 Neuroblastoma-Cells. Molecular biology of the cell,6.
  • Shea, T.B. (1994). Amyloid Precursor Protein as a Glial-Derived Growth Factor. Trends in neurosciences,17(8) 338-339.
  • Shea, T.B., Beermann, M.L., Griffin, W.R., Leli, U. (1994). Degradation of Protein Kinase C and Its Free Catalytic Subunit, Protein Kinase M, in Intact Human Neuroblastoma Cells and Under Cell-Free Conditions: Evidence That PKM Is Degraded by mM Calpain-Mediated Proteolysis at a Faster Rate Than PKC. FEBS letters,350(2�"3) 223-229.
  • Shea, T.B. (1994). Triton-Soluble Phosphovariants of the High Molecular Weight Neurofilament Subunit from NB2a/Dl Cells Are Assembly-Competent: Implications for Normal and Abnormal Neurofilament Assembly. FEBS letters,343(2) 131-136.
  • Leli, U., Shea, T.B., Cataldo, A., Hauser, G., Grynspan, F., Beermann, M.L., Liepkalns, V.A., Nixon, R.A., Parker, P.J. (1993). Differential Expression and Subcellular Localization of Protein Kinase C Alpha, Beta, Gamma, Delta, and Epsilon Isoforms in SH-SY5Y Neuroblastoma Cells: Modifications During Differentiation. Journal of neurochemistry,60(1) 289-98.
  • Shea, T.B., Beermann, M.L. (1993). Evidence That the Monoclonal Antibodies SMI-31 and SMI-34 Recognize Different Phosphorylation-Dependent Epitopes of the Murine High Molecular Mass Neurofilament Subunit. Journal of neuroimmunology,44(1) 117-121.
  • Shea, T.B., Balikian, P., Beermann, M.L. (1992). Aluminum Inhibits Neurofilament Protein Degradation by Multiple Cytoskeleton-Associated Proteases. FEBS letters,307(2) 195-198.
  • Shashoua, V.E., Nolan, P.M., Shea, T.B., Milinazzo, B. (1992). Dibutyryl Cyclic AMP Stimulates Expression of Ependymin mRNA and the Synthesis and Release of the Protein into the Culture Medium by Neuroblastoma Cells (NB2a/d1). Journal of neuroscience research,32(2) 239-44.
  • Leli, U., Cataldo, A., Shea, T.B., Nixon, R.A., Hauser, G. (1992). Distinct Mechanisms of Differentiation of SH-SY5Y Neuroblastoma Cells by Protein Kinase C Activators and Inhibitors. Journal of neurochemistry,58(4) 1191-8.
  • Leli, U., Parker, P.J., Shea, T.B. (1992). Intracellular Delivery of Protein Kinase C- or Isoform-Specific Antibodies Promotes Acquisition of a Morphologically Differentiated Phenotype in Neuroblastoma Cells. FEBS letters,297(1�"2) 91-94.
  • Shea, T.B., Beermann, M.L. (1992). Regulation of Neuronal Migration and Neuritogenesis by Distinct Surface Proteases Relative Contribution of Plasmin and a Thrombin-Like Protease. FEBS letters,307(2) 190-194.
  • Fischer, I., Shea, T.B. (1991). Differential Appearance of Extensively Phosphorylated Forms of the High Molecular Weight Neurofilament Protein in Regions of Mouse Brain During Postnatal Development. Journal of neuroimmunology,31(1) 73-81.
  • Shea, T.B., Beermann, M.L., Nixon, R.A. (1991). Multiple Proteases Regulate Neurite Outgrowth in NB2a/Dl Neuroblastoma Cells. Journal of neurochemistry,56(3) 842-51.
  • Shea, T.B., Beermann, M.L. (1991). Staurosporine-Induced Morphological Differentiation of Human Neuroblastoma Cells. Cell biology international reports,15(2) 161-168.
  • Shea, T.B. (1991). Transient Neuritogenesis in NB2a/d1 Neuroblastoma Cells Induced by Glial-Derived Protease Inhibitors. Cell biology international reports,15(5) 437-443.
  • Shea, T.B., Beermann, M.L. (1990). Alterations in Dynamics of Microtubule Assembly During Axonal Neuritogenesis in NB2a/d1 Cells. Cell biology international reports,14(12) 1093-1098.
  • Shea, T.B. (1990). Neuritogenesis in Mouse NB2a/d1 Neuroblastoma Cells: Triggering by Calcium Influx and Involvement of Actin and Tubulin Dynamics. Cell biology international reports,14(11) 967-979.
  • Shea, T.B., Beermann, M.L., Nixon, R.A. (1990). Post-Translational Modification of -Tubulin by Acetylation and Detyrosination in NB2a/d1 Neuroblastoma Cells. Developmental Brain Research,51(2) 195-204.
  • Shea, T.B. (1990). Transient Increase in Vimentin in Axonal Cytoskeletons During Differentiation in NB2a/d1 Cells. Brain research,521(12) 338-342.
  • Shea, T.B., Clarke, J.F., Wheelock, T.R., Paskevich, P.A., Nixon, R.A. (1989). Aluminum Salts Induce the Accumulation of Neurofilaments in Perikarya of NB2a/Dl Neuroblastoma. Brain research,492(12) 53-64.
  • Shea, T.B., Beermann, M.L., Nixon, R.A. (1989). Appearance and Localization of Phosphorylated Variants of the High Molecular Weight Neurofilament Protein in NB2a/d1 Cytoskeletons During Differentiation. Developmental Brain Research,50(1) 142-146.
  • Shea, T.B., Nixon, R.A. (1988). Differential Distribution of Vimentin and Neurofilament Protein Immunoreactivity in NB2a/d1 Neuroblastoma Cells Following Neurite Retraction Distinguishes Two Separate Intermediate Filament Systems. Developmental Brain Research,41(1�"2) 298-302.
  • Newburg, D.S., Shea, T.B., Yatziv, S., Raghavan, S.S., McCluer, R.H. (1988). Macrophages Exposed in Vitro to Conduritol B Epoxide Resemble Gaucher Cells. Experimental and molecular pathology,48(3) 317-323.
  • Shea, T.B., Sihag, R.K., Nixon, R.A. (1988). Neurofilament Triplet Proteins of NB2a/d1 Neuroblastoma: Posttranslational Modification and Incorporation into the Cytoskeleton During Differentiation. Developmental Brain Research,43(1) 97-109.
  • Shea, T.B., Majocha, R.E., Marotta, C.A., Nixon, R.A. (1988). Soluble, Phosphorylated Forms of the High Molecular Weight Neurofilament Protein in Perikarya of Cultured Neuronal Cells. Neuroscience letters,92(3) 291-297.
  • Fischer, I., Nolan, C.E., Shea, T.B. (1987). Effects of Retinoic Acid on Expression of the Transformed Phenotype in C6 Glioma Cells. Life Sciences,41(4) 463-470.
  • Fischer, I., Shea, T.B., Sapirstein, V.S., Kosik, K.S. (1986). Expression and Distribution of Microtubule-Associated Protein 2 (MAP2) in Neuroblastoma and Primary Neuronal Cells. Developmental Brain Research,25(1) 99-109.
  • Shea, T.B., Fischer, I., Sapirstein, V.S. (1985). Effect of Retinoic Acid on Growth and Morphological Differentiation of Mouse NB2a Neuroblastoma Cells in Culture. Developmental Brain Research,21(2) 307-314.

Selected Presentations

  • Pathways to Hope: the latest in Alzheimers research - MA/NH Alzheimers Association Conference, 2009 - Plymouth, NH
  • Nutrition in aging and Alzheimers disease, 2008 - Essex County Professional Networking Group, Peabody MA
  • Results of clinical trials of the SmartPill: a vitamin/nutriceutical formulation that improves cognition and mood in early-stage Alzheimers patients and in seniors without dementia. - Alzheimers Workshop, 2007 - Plymouth MA
  • Nutrition and Alzheimers disease, 2007 - Douville Senior Center, Tewksbury, MA
  • Nutrition and cognition in aging and Alzheimers disease, 2007 - Merrimack Valley River House, Lowell, MA
  • The SmartPill: stopping Alzheimers disease where it starts, 2007 - Emerald Court, Tewksbury, MA
  • An over-the-counter nutriceutical formulation that prevents neuronal oxidative damage, acetylcholine depletion, cognitive decline and buffers Alzheimer risk factors in preclinical studies: are we ready for clinical trials?, 2006 - BU Med School, Boston, MA
  • Clinical trials of apple juice to delay cognitive decline in Alzheimers disease, 2006 - Youville Senior Center, Tewksbury, MA
  • Nutriceutical Formulation 1: a vitamin/nutriceutical formulation that improves cognition and mood in early-stage Alzheimers patients and in seniors without dementia, 2006 - Chicago , Il
  • The SmartPill: clinical trials of a vitamin/nutriceutical formulation that improves cognition and mood in early-stage Alzheimers patients and in seniors without dementia, 2006 - Fallon Clinic, MA
  • Microtubule motors and neurofilament dynamics, 2005 - Drexel University, Philadelphia, PA
  • Folate and Alzheimers disease - Alzheimers Assocation: Map thru the Maze, 2004 - Malboro, MA
  • Brain Nutrients: How folates are linked to Alzheimers disease, 2004 - East Village Place (Assisted Living Group) East Longmeadow, MA
  • Health Benefits from Eating Apples, 2004 - Manchester NH
  • Is Diet a Major Factor in the Occurrence of Alzheimer's Disease? - Explorations in Chemical Education Conference, 2003 - Middlesex Community College, Lowell MA
  • "Suprastructure of Axonal Neurofilaments" - 7th Intermediate Filament Gordon Conference, 2002 - Roger Bristol University, Newport, RI
  • Neurofilament dynamics as revealed by green fluorescent protein, 2002 - Nathan Kline Institute, Orangeburg, NY
  • Nutritional Approaches to Treat Alzheimers Disease, 2002 - The Atrium, Danvers MA
  • Microtubule motors, phosphorylation and neurofilament axonal transport, 2001 - McGill University, CA
  • Motors, kinases and neurofilament axonal transport, 2001 - SUNY at Albany
  • "Microtubule motors, phosphorylation and neurofilament transport of Triton-soluble and -insoluble neurofilament subunits" - 6th Intermediate Filament Gordon Conference, 2000 - Queens College, Oxford, UK
  • Neurofilament transport and phosphorylation, 2000 - NIH, Bethesda, MD
  • "Research Update: Current research on causes, medications and other treatments", 1999 - Lowell, MA
  • "Recent developments in understanding of Alzheimer's disease neuropathology", 1998 - McLean Hospital Grand Rounds, Belmont, MA
  • "Recent developments in understanding of Alzheimer's disease neuropathology", 1998 - Lowell, MA
  • "Axonal transport of Triton-soluble and -insoluble neurofilament subunits" in Neuropathology and Intermediate Filaments - 5th Intermediate Filament Gordon Conference, 1998 - Holderness, New Hampshire
  • Creation of a "virtual" journal club using a threaded newsgroup - Institutional Technology Conference, 1997 - Boxboro, MA
  • Phosphatidyl serine alters tau antigenicity and phosphorylation by a non-PS-dependent kinase - Mass Alzheimer's Disease Scientific Symposium, 1997 - Boston, MA
  • TGF-2 dependent protection towards and exacerbation of beta-amyloid toxicity. - Mass Alzheimer's Disease Scientific Symposium, 1997 - Boston, MA
  • Initial transport of neurofilament subunits in mouse optic pathway occurs at a rate in excess of slow component a: correlation of slowing of transport with neurofilament phosphorylation - Workshop on Neuronal Plasticity, Development and Regeneration, 1997 - University of Massachusetts at Lowell, Lowell, MA
  • Pivotal role of the calpain/PKC system in neuronal differentiation and degeneration, 1996 - McLean Hospital, Belmont, MA
  • Pivotal role of the calpain/PKC system in neuronal differentiation and degeneration, 1996 - St. Elizabeth's Hospital, Boston, MA
  • Pivotal role of the calpain/PKC system in neuronal homeostasis, 1996 - Bayer Corporation, New Haven, CT
  • Lipids inhibit mM calpain-mediated PKC proteolysis - 26th Annual Meeting of the American Society for Neurochemistry, 1995 - Santa Monica, CA
  • Sequential cytoskeletal protein requirements for axonal outgrowth and stabilization - 25th Annual Meeting of the American Society for Neurochemistry, 1994 - Albequerque, New Mexico
  • Sequential requirement for cytoskeletal and membrane skeletal proteins for axonal neurite initiation, outgrowth and stabilization, 1994 - Hershey Medical Center, Hershey, PA
  • Sequential requirement for cytoskeletal and membrane skeletal constituents for axonal neurite initiation, outgrowth and stabilization, 1993 - University of Massachusetts at Lowell, Lowell, MA
  • Potential involvement of neuronal surface proteinases and their glial-derived inhibitors in the nervous system - 21st Annual Meeting of the American Society for Neurochemistry, 1991 - Charleston, South Carolina
  • Soluble 200 kDa NF-H in mouse brain during postnatal development - 21st Annual Meeting of the American Society for Neurochemistry, 1991 - Charleston, South Carolina
  • Sequential requirement of cytoskeletal constituents for initiation and maturation of axonal neurites, 1991 - E. K. Shriver Center for Mental Retardation, Waltham, Massachusetts
  • Cytoskeletal dynamics accompanying axonal outgrowth in cultured neuronal cells - 1st Annual Biology of Neuronal Disorders International Workshop, 1990 - Belmont, Massachusetts
  • Epigenetic events in the induction of axonal neurites: Dependence upon microenvironmental clues, 1990 - Boston University School of Public Health, Boston, Massachusetts
  • Vimentin and neurofilament expression during axon outgrowth in vitro - 20th Annual Meeting of the American Society for Neurochemistry, 1989 - Chicago, Illinois
  • Argyrophilic deposits form in perikarya of aluminum-treated NB2a/d1 cells - 19th Annual Meeting of the American Society for Neurochemistry, 1988 - New Orleans, Louisiana
  • Phosphorylated 200kD neurofilament protein in NB2a/d1 perikarya - 19th Annual Meeting of the American Society for Neurochemistry, 1988 - New Orleans, Louisiana
  • Maintenance of axonal stability: Relationship to posttranslational modification of cytoskeletal proteins - 1st Annual American Federation for Aging Research Conference, 1988 - Briarcliff Manor, New York
  • Cytoskeletal dynamics during early stages of differentiation in cultured neurons, 1988 - E. K. Shriver Center for Mental Retardation, Waltham, Massachusetts
  • Induction of "neurofibrillary pathology" in NB2a/d1 neuroblastoma cells, 1987 - Eunice Kennedy Shriver Center for Mental Retardation, Waltham, Massachusetts
  • Expression of neurofilament proteins by differentiated neuroblastoma cells., 1986 - Eunice Kennedy Shriver Center for Mental Retardation, Waltham, Massachusetts
  • Synthesis of a neural plasma membrane proteolipid - 16th Meeting of the American Society for Neurochemistry, 1985 - Baltimore, Maryland
  • Process outgrowth in cultured embryonic rat neurons - 35th Meeting of the Tissue Culture Association, 1984 - Houston, Texas
  • Spectrin-binding protein, Band 4.1, in glial cells, 1984
  • A serum-free medium for fish cell cultures, 1983
  • Air Bladder-III cells: a new continuous cell line from goldfish, 1983
  • Pesticides and viral infections: are "safe" levels of pesticides truly safe?, 1983 - Massachusetts State Laboratories, Boston, Massachusetts
  • Suppression of an interferon-like activity as a possible mechanism for enhancement of Goldfish Virus-2 by the pesticide carbaryl - Phi Sigma Symposium, 1983 - Marine Science Institute, Nahant, Massachusetts
  • Interaction of Iridovirus GFV-2 in vitro with the pesticides carbaryl and toxaphene, 1982
  • Interactions of the pesticides toxaphene and carbaryl with viruses and cell cultures derived from Carassius auratus - Phi Sigma Symposium, 1982 - Marine Science Institute, Nahant, Massachusetts
  • Replication and physicochemical properties of two Iridovirus isolates from goldfish (Carassius auratus), 1982
  • A flagellartropic bacteriophage of Bacillus subtilis - XIII International Congress for Microbiology, 1982
  • Goldfish Virus-2 (GFV-2): A new Iridovirus isolated from Carassius auratus - Phi Sigma Symposium, 1981 - Marine Science Institute, Nahant, Massachusetts

Selected Intellectual Property

  • Patent - Shea, T.B."An over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in AlzheimerÍs disease and normal aging.," UML-08-04
  • Patent - Shea, T.B."An Anti-Oxidant Synergy Formulation that promotes neuronal survival and prevents neurodegeneration," UML-97-14-19

Selected Contracts, Fellowships, Grants and Sponsored Research

  • (2013), - National Science Foundation
    Shea, T. (Principal)
  • Dietary Supplementation with a Nutriceutical Formulation to Delay Motor Neuron De (2011), -
    Shea, T.B. (Principal)
  • (2011), - Army Research Office
    Shea, T. (Principal)
  • Development and Refinement of a Computer/Neuronal Robotics Interface (2011), Grant -
    Shea, T.B. (Principal)
  • Equipment to Support Development of Neuronal Network Controlled Robots (2013), Contract -
    Shea, T.B. (Co-Principal)
  • (2012), - Adelard A and Valeda Lea Roy Foundation
    Shea, T. (Principal)
  • (2008), - AlzheimerÍs Association
    Shea, T. (Principal)
  • (2010), - National Science Foundation
    Shea, T. (Principal)
  • How Does Phosphorylation Regulate Neurofilament Transport? (2009), Grant -
    Shea, T.B. (Principal)
  • Model of Learning in Neuronal Culture (2010), Grant -
    Shea, T.B. (Principal)
  • (2009), - US Army
    Shea, T. (Principal)
  • (2007), - National Institute on Aging
    Shea, T. (Principal)
  • (2003), - US Apple Products Research and Education Council
    Shea, T. (Principal)
  • Optimization of a Neuronal-computer Interface (2008), Contract -
    Shea, T.B. (Principal)
  • (2008), - National Institute of Health
    Shea, T.
  • (2007), - National Institute on Aging
    Shea, T. (Principal)
  • (2006), - US Apple Products Research and Education Council
    Shea, T. (Principal)
  • (2004), - National Pecan Shellers Association
    Shea, T. (Principal)
  • A preclinical trial of Memacin for neuroprotection and cognitive benefit (2007), Grant -
    Shea, T.B. (Principal)
  • (2007), - US Army
    Shea, T. (Principal)
  • Subcontract from US Army STTR to Infoscitex Corp (2006), Contract -
    Shea, T. (Principal)
  • (2006), - UMass Lowell Chancellors Fund
    Shea, T. (Principal)
  • (1999), - National Science Foundation
    Shea, T. (Principal)
  • (2004), - National Institutes of Health
    Shea, T. (Principal)
  • (2002), - AlzheimerÍs Association
    Shea, T. (Principal)
  • (2003), - National Science Foundation
    Shea, T.
  • (2003), - National Science Foundation
    Shea, T.
  • (2002), - Processed Apples Institute
    Shea, T. (Principal)
  • UMass Lowell Healy Grant (2002), Grant -
    Shea, T. (Principal)
  • (2000), - UMass Lowell Research Foundation
    Shea, T. (Co-Principal)
  • (1997), - National Institutes of Health
    Shea, T.
  • (1998), - National Science Foundation
    Shea, T. (Principal)
  • (1998), - Office of Elder Affairs
    Shea, T. (Principal)
  • (1997), - National Science Foundation
    Shea, T. (Principal)
  • (1996), - National Science Foundation
    Shea, T. (Co-Principal)
  • (1994), - National Institute on Aging
    Shea, T. (Principal)
  • (1996), - Amyotrophic Lateral Sclerosis Association
    Shea, T. (Principal)
  • Joseph P. Healey Endowment (1996), Grant -
    Shea, T. (Principal)
  • (1991), - National Institute of Mental Health
    Shea, T. (Principal)
  • (1995), - Massachusetts Alzheimer's Disease Research Center Program Project, National Institutes on Aging
    Shea, T. (Principal)
  • R01 Subproject in Leadership and Excellence in Alzheimer's Disease (LEAD) Program Project (1992), -
    Shea, T.
  • (1990), - National Science Foundation
    Shea, T. (Principal)
  • Massachusetts Alzheimer's Disease Research Center Program Grant (1989), Grant - National Institutes of Health
    Shea, T. (Co-Principal)
  • (1988), - National Science Foundation
    Shea, T. (Principal)
  • (1990), - Alzheimer's Association
    Shea, T. (Principal)
  • William F. Milton Fund Award (1991), -
    Shea, T. (Principal)
  • (1988), - Amyotrophic Lateral Sclerosis Association, Inc.
    Shea, T. (Principal)
  • (1987), - Medical Foundation, Inc.
    Shea, T. (Principal)
  • (1987), - American Foundation for Aging Research, Inc
    Shea, T. (Principal)