Susan J. Braunhut

Expertise

Radiation Therapy and Medical Countermeasures for Radiological Terrorism; Development of Novel Cancer Treatments and Biosensors for Toxicity Testing and Cancer Diagnosis

Research Interests

Tissue Regeneration; Ionizing Radiation Therapy for Human Cancer; Hyperthermia; Breast Cancer; Vascular Biology; Extracellular Matrix

Scientists in my laboratory are devising new technologies to allow the rapid diagnosis of cancer and assess the risk of metastasis. In addition, we are testing new approaches to treatment of cancer using chemotherapeutic agents, ionizing radiation and hyperthermia. We are currently developing methods that will assist oncologists in predicting whether or not a particular cancer will respond to a given therapy. Using the tools of cell culture, biochemistry and immunology we are searching for new therapies that will shut-down blood supply to tumors or trigger apoptosis, programmed cell death, of tumor cells taken from patients or experimental animals.

Education

• Ph D: Pathobiology, (1982), Columbia University - New York, NY
• MS: Pathobiology, (1980), Columbia University - New York, NY
• MA: Physiological Psychology, (1977), University of Hartford - Hartford, Connecticut
• BA: Physiological Psychology, (1974), Kent State University - Kent, Ohio

Biosketch

Braunhut has supported her independent research laboratory since 1986 through extramural funding acquisition from federal sources (DOD, DARPA, NIH, NSF) while teaching and performing service at the university and within the community. Braunhut has worked continuously in the areas of cancer therapy and diagnosis, radiobiology and biosensors. Her current laboratory includes full-time research staff and undergraduate, graduate and postdoctoral students conducting research in these areas. Braunhut serves as a reviewer for three national study sections and reviews manuscripts for numerous journals. Her work has been published in nationally recognized and international journals.  Braunhut was elected University Professor in September 2008. The title of University Professor is the most esteemed title bestowed on faculty at UMass Lowell. The honor recognizes an individual who, over a period of years, has consistently demonstrated exemplary teaching, nationally significant research, and extraordinary service to the university community. The professorship ran from September 2008 through August 2011. She became a Fulbright Scholar in 2011 and serves now as a Fulbright scholar review panelists. She is also a Aspen Institute Scholar.  Braunhut is a member of the faculty development committee at UMass Lowell. The committee activities foster interdisciplinary communities within and across departments and colleges, leading to an engaged faculty and to inspire and assist the faculty to realize their highest potential for teaching, research, scholarship, and service throughout a productive career.

Selected Awards and Honors

• Fulbright Scholar in Biology Education (2012) - Council for International Exchange of Scholars
• Planned and presented at first University Professors Tea (2010), Service, Professional - UMass Lowell
• Appointed Visiting Full Professor of Applied and Theoretical Biology (2009), Service, Professional - Kwame Nkrumah University of Science and Technology, Ghana, West Africa
• Appointed to Chair the Chancellor's Task Force on Collaborative Research (2004)
• Appointed to Chancellor's Task Force on the Research Foundation Trust (2003)
• Appointed to College Grievances Committee (2000) - Chancellor
• Faculty Representative of the Federal Demonstration Partnership (1998)
• Appointed to UMass Lowell System-wide Conflict of Interest Committee (1997) - Chancellor
• Appointed to University Radiation Safety Committee (1997) - Chancellor
• Elected to Federal Demonstration Partnership Executive Committee (1997) - National Academy of Science
• Appointed to National Federal Demonstration Partnership (1996) - Chancellor
• Appointed to UMass Lowell System-wide CVIP Life Sciences Patent Evaluation Committee (1996) - Chancellor
• American Men and Women of Science (1995), Service, Professional
• Who's Who in Frontiers of Science and Technology (1995), Service, Professional
• Young Investigator (1990) - American Heart Association Award
• Young Investigator (1986) - National Institutes of Health R29 Award
• Public Health National Student Research Training Award (1983)
• First Prize - Ralph D. Lillie Award (1982) - Society of Histochemistry and Cytochemistry

Selected Publications

• Zhang, J., Nagarajan, S., Kumar, J., Tries, M., Braunhut, S.J. (2012). Mitigation of Radiation-Induced Apoptosis of Human Lung Microvascular Endothelial Cells Using a New Semi-Synthetic Oligoepicatechin. Free Radical Biology and Medicine.
• Wang, G., Zhang, J., Dewilde, A.H., Pal, A.K., Bello, D., Therrien, J.M., Braunhut, S.J., Marx, K.A. (2012). The LDH Cellular Cytotoxicity Assay: Correcting Assay Errors Due to the Presence of Carbon Nanostructures.
• Dewilde, A.H., Wang, G., , Marx, K.A., Therrien, J.M., Braunhut, S.J. (2012). Use of the Quartz Crystal Microbalance (QCM) to Measure Mitochondrial Depolarization in Real Time and Predict Chemically-Induced Apoptosis of Human Pulmonary Endothelial Cells and Macrophages. Analytical Biochemistry.
• Wang, G., Dewilde, A., Zhang, J., Pal, A., Vashist, M., Bello, D., Braunhut, S.J., Marx, K.A., Therrien, J.M. (2011). A Living Cell Quartz Crystal Microbalance Device for Continuous Monitoring of Cytotoxic Responses of Macrophages to Single-Walled Carbon Engineered Nanoparticles. Particle and Fibre Toxicology, 8(4).
• Zhou, T., Marx, K.A., Dewilde, A.H., McIntosh, D., Rugh, A., Braunhut, S.J. (2011). Dynamic Cell Adhesion and Viscoelastic Signatures Distinguish Normal from Malignant Human Mammary Cells Using Quartz Crystal Microbalance. Analytical Biochemistry, 42 164-171.
• Zhang, J., Dewilde, A., Chinn, P., Foreman, A., Barry, S., Kanne, D., Braunhut, S.J. (2011). Herceptin-Directed Nanoparticles Activated by an Alternating Magnetic Field Selectively Kill Her-2 Positive Human Breast in Vitro via Hyperthermia. International Journal of Hyperthermia, 27 682-697.
• Hechavarria, D., Dewilde, A., Braunhut, S.J., Levin, M., Kaplan, D.L. (2010). Biodome Regenerative Sleeve for Biochemical and Biophysical Stimulation of Tissue Regeneration. Medical engineering & physics, 32(9) 1065-1073.
• Vorotnikova, E., McIntosh, D., Dewilde, A., Zhang, J., Reing, J., Zhang, L., Cordero, K., Bedelbaeva, K., Gourevitch, D., Heber-Katz, E., Badylak, S., Braunhut, S.J. (2010). MRL Cell Matrix-Derived Products Modulate Endothelial and Progenitor Cell Migration and Proliferation in Vitro and Stimulate Regenerative Healing in Vivo. Matrix Biology, 29 690-700.
• Wang, G., Badylak, S.F., Heber-Katz, E., Braunhut, S.J., Gudas, L.J. (2010). The Effects of DNA Methyltransferase Inhibitors and Histone Deacetylase Inhibitors on Digit Regeneration in Mice. Regenerative Medicine, 5(2) 201-220.
• Vorotnikova, E., Rosenthal, R., Tries, M., Doctrow, S., Braunhut, S.J. (2010). Novel Synthetic SOD Mimetics Can Mitigate Capillary Endothelial Cell Apoptosis Caused by Ionizing Radiation. Radiation research, 173 748-759.
• Agrawal, V., Johnson, S., Reing, J., Zhang, L., Tottey, S., Wang, G., Hirschi, K., Braunhut, S.J., Gudas, L., Badylak, S. (2010). An Epimorphic Regeneration Approach to Tissue Replacement in Adult Mammals. Proceedings of the National Academy of Sciences of the United States of America, 107(8) 3351-3355.
• Nagarajan, S., Nagarajan, R., Braunhut, S.J., Bruno, F., McIntosh, D., Samuelson, L., Kumar, J. (2008). Biocatalytically Oligomerized Epicatechin with Potent and Specific Anti-Proliferative Activity for Human Breast Cancer Cells. Molecules, 13 2704-2716.
• Reing, J., Zhang, I., Myers-Irvin, J., Cordero, K.E., Freytes, D.O., Heber-Katz, E., Bedelbaeva, K., McIntosh, D., Dewilde, A., Braunhut, S.J., Badylak, S.F. (2008). Degradation Products of Extracellular Matrix Affect Cell Migration and Proliferation. Tissue Engineering - Part A, 15 605-614.
• Marx, K.A., Zhou, T., McIntosh, D., Braunhut, S.J. (2008). Electropolymerized Tyrosine-Based Thin Films: Selective Cell Binding via Peptide Recognition to Novel Electropolymerized Biomimetic Tyrosine RGDY Films. Analytical Biochemistry, 384 86-95.
• Marx, K.A., Zhou, T., Montrone, A., McIntosh, D., Braunhut, S.J. (2007). A Comparative Study of the Cytoskeleton Binding Drugs Nocodazole and Taxol with a Mammalian Cell Quartz Crystal Microbalance Biosensor: Different Dynamic Responses and Energy Dissipation Effects. Analytical Biochemistry, 361 77-92.
• Vorotnikova, E., Ivkov, R., Foreman, A., Tries, M., Braunhut, S.J. (2006). The Magnitude and Time-Dependence of the Apoptotic Response of Normal and Malignant Cells Subjected to Varying Treatments of Ionizing Radiation. International journal of radiation biology, 82 549-559.
• Braunhut, S.J., McIntosh, D., Vorotnikova, E., Zhou, T., Marx, K.A. (2005). Detection of Apoptosis and Drug Resistance of Human Breast Cancer Cells to Taxane Treatments Using Quartz Crystal Microbalance Biosensor Technology. Assay and Drug Development Technologies, 3 1-12.
• Marx, K.A., Zhou, T., Montrone, A., McIntosh, D., Braunhut, S.J. (2005). Quartz Crystal Microbalance Biosensor Study of Endothelial Cells and Their Extracellular Matrix Following Cell Removal: Evidence for Transient Cellular Stress and Viscoelastic Changes During Detachment and the Elastic Behavior of the Pure Matrix. Analytical Biochemistry, 343 23-34.
• Braunhut, S.J., MacIntosh, D., Vorotnikova, E., Zhou, T., Marx, K. (2004). Development of Smart Bandage: Applying Electrical Potential to Selectively Release Wound Healing Growth Factors from Cell Free Extracellular Matrices. MRS, 711 31-33.
• Marx, K., Zhou, T., MacIntosh, D., Braunhut, S.J. (2004). Extracellular Matrix Studied with the Quartz Crystal Microbalance: Cellular Stress During Removal and the Elastic Behavior of the Matrix. Material Research, 711 11-13.
• Vorotnikova, K., Triesb, M., Braunhut, S.J. (2004). Radiation Induced Apoptosis in Capillary Endothelial Cells: Protection by Retinoids and Tissue Inhibitors of Matrix Metalloproteinases (TIMP). Radiation research, 161 174-184.
• Vorotnikova, E., Tries, M.A., Braunhut, S.J. (2004). Retinoids and TIMP1 Prevent Radiation-Induced Apoptosis of Capillary Endothelial Cells. Radiation research, 161(2) 174–184.
• Marx, K.A., Zhou, T., Warren, M., Braunhut, S.J. (2003). Quartz Crystal Microbalance Study of Endothelial Cell Number Dependent Differences in Initial Adhesion and Steady State Behavior: Evidence for Cell-Cell Cooperativity in Initial Adhesion and Spreading. Biotechnology progress, 19 987-999.
• Marx, K.A., Zhou, T., Montrone, A., Braunhut, S.J. (2002). A Quartz Crystal Microbalance Cell Biosensor Detecting Nocodazole Dependent Microtubule Disruption Dynamics in Living Cells. Advanced Biomaterials, 711 125-132.
• Marx, K.A., Zhou, T., Schulze, H., Braunhut, S.J. (2001). A Quartz Crystal Microbalance Cell Biosensor: Detection of Microtubule Alterations in Living Cells at Nm Nocodazole Concentrations. Bioelectronics & Biosensors, 16 773-782.
• Warren, M.C., Medeiros, D., Bump, E.A., Braunhut, S.J. (2000). Oxidative Stress-Induced Apoptosis of Endothelial Cells: The Role of Matrix Metalloproteinases. Free Radical Biology & Medicine, 29 537-547.
• Zhou, T., Marx, K.A., Warren, M., Schulze, H., Braunhut, S.J. (2000). The Quartz Crystal Microbalance as a Continuous Monitoring Tool for the Study of Endothelial Cell Surface Attachment and Growth. Biotechnology progress, 16 268-277.
• Zhou, T., Braunhut, S.J., Medeiros, D., Marx, K.A. (1999). Cellular Adhesion and Spreading of Endothelial Cells Monitored in Real Time Using the Quartz Crystal Microbalance. Materials Research, 550 177-182.
• van Kleef, E.M., te Poele, J.A., Oussoren, Y.G., Verheij, M., van de Pavert, I., Braunhut, S.J., Dewit, L.G., Stewart, F.A. (1998). Increased Expression of Glomerular von Willebrand Factor after Irradiation of the Mouse Kidney. Radiation research, 150 528-534.
• Zhou, T., Braunhut, S.J., Medeiros, D., Marx, K.A. (1998). Potential Dependent Endothelial Cell Adhesion, Growth and Cytoskeletal Rearrangement. Material Research, 489 211-216.
• Braunhut, S.J. (1997). Protection Against Radiation Damage to Vascular Tissue (pp. 325-341). CRC Press, Inc.
• Langley, R.D., Bump, E.A., Quartuccio, S.G., Medeiros, D., Braunhut, S.J. (1997). Radiation-Induced Apoptosis in Microvascular Endothelial Cells. British journal of cancer, 75 666-672.
• Braunhut, S.J., Medeiros, D., Cerce, B.A., Lai, L.L., Bump, E.A. (1996). The Effects of TEMPOL and Ionizing Radiation on the Endothelial Cell Wound Healing Response. British journal of cancer, 74 157-161.
• Kostyk, S., Kourembanas, S., Wheeler, E., Medeiros, D., McQuillan, L., D'Amore, P., Braunhut, S.J. (1995). Basic Fibroblast Growth Factor Increases Nitric Oxide Synthase Production in Bovine Endothelial Cells. American Journal of Physiology, 269 1583-1589.
• Bump, E.A., Braunhut, S.J., Palayoor, S.T., Medeiros, D., Lai, L.L., Cerce, B., Langley, R.E., Coleman, C.N. (1994). Novel Concepts in Modification of Radiation Sensitivity. International Journal Radiation Oncology Biol. Phys., 29 249-253.
• Braunhut, S.J., Moses, M.A. (1994). Retinoids Modulate Endothelial Cell Production of Matrix-Degrading Proteases and Tissue Inhibitors of Metalloproteinases (TIMP). Journal of Bio. Chem. , 269(18) 13472-13479.
• Braunhut, S.J., D'Amore, P.A., Gudas, L. (1992). The Location and Expression of Fibroblast Growth Factor (FGF) by f9 Visceral and Parietal Embryonic Cells After Retinoic Acid-Induced Differentiation. Differentiation, 50 141-152.
• Braunhut, S.J., Palomares, M. (1991). Modulation of Endothelial Cell Shape and Growth by Retinoids. Microvascular Res. , 47-62.
• Paige, K., Palomares, M., D'Amore, P., Braunhut, S.J. (1991). Retinol-Induced Modification of the Extracellular Matrix of Endothelial Cells: Its Role in Growth Control. In Vitro Cellular Developmental Biology, 27 151-157.
• Braunhut, S.J., Rufo, G., Ernisse, B., Zheng, W., Bellve', A. (1990). The Seminiferous Growth Factor Induces Proliferation of TM 4 Cells in Serum-Free Media. Biologoical Reproduction, 42 639-648.
• Braunhut, S.J., Gudas, L.J., Kurokawa, T., Sasse, J., D'Amore, P.A. (1989). Expression of Fibroblast Growth Factor by F9 Teratocarcinoma Cells as a Function of Differentiation. Journal of Cell Biology, 108 2467-2476.
• D'Amore, P., Braunhut, S.J. (1988). Stimulatory and Inhibitory Factors in Vascular Growth Control (pp. 13-36). CRC Press, Inc.
• Persson, H., Gray, H.D., Godeau, F., Braunhut, S.J., Bellve', A.R. (1986). Multiple Growth-Associated Unclear Proteins Immunoprecipitated by Antisera Against Human c-myc Peptide Antigens. Molecular Cell Biology, 6 942-949.
• Bellve, A.R., Stewart, T.A., Braunhut, S.J., Ernisse, B.J., Rufo, G.A. (1986). The Seminiferous Growth Factor (SGF): A Candidate for Regulating Cell Proliferation During Development of the Mammalian Testes. Proc. Australian Soc. Study Reproduction, 8 10-22.
• Braunhut, S.J., Blanc, W.A., Ramanarayanan, M., Marboe, C., Mesa-Tejada, R. (1984). Immunocytochemical Localization of Lysozyme and Alpha-1-Antichymotrypsin in the Term Human Placenta: An Attempt to Characterize the Hofbauer Cell. Journal of Histochem Cytochem., 32 1204-1210.
• Lefkowitch, J.H., Muschel, R., Price, J.B., Marboe, C., Braunhut, S.J. (1983). Copper and Copper-Binding Protein in Fibrolamellar Liver Cell Carcinoma. Cancer, 51 97-100.
• Friedman, A.H., Orellana, J., Freeman, W.R., Luntz, M.H., Starr, M.B., Tapper, M.L., Spigland, I., Roterdam, H., Mesa-Tejada, R., Braunhut, S.J., Mildvan, D., Mathur, U. (1983). Cytomegalovirus Retinitis: A Manifestation of the Acquired Immune Deficiency Syndrome (AIDS). Br J Ophthalmol, 67 372-380.

Selected Presentations

• Toxicity of Nanomaterials in the Environment - NSF grantee conference, December 2012 - Arlington, VA
• The Nanocanary. A Cell-Based Biosensor to Evaluate Cellular Responses to Drugs and Toxins - Early Stages Life Sciences Technology Conference, April 2012 - Merck Research Laboratories, Harvard Medical School
• The Nanocanary as an Environmental Monitor - Environmental Implications of Nanotechnology, May 2011 - Duke University
• Injection Molding of Synthetic Materials - ANTEC 2011, May 2011 - Hynes Convention Center, Boston, MA
• - Life Cycle Assessment of Nanomaterials , February 2011
• Commercialization of Biosensors, November 2010 - North Chelmsford, MA
• - Ideation conference, October 2010
• , October 2010 - Brown University
• The Nanocanary: A New Device to Detect Nanomaterial Toxicity - Destination Nanotechnology Conference, ICC, September 2010
• - Pre-ideation commercialization conference, September 2010
• To Grow Back a Lost Human Limb: The Challenges and Promise of Regenerative Medicine - Professor Annual Lecture Symposium, May 2010 - Kumasi, Ghana West Africa
• - Emerging Technologies Conference of US-Ireland Partnership, October 2009
• The Use of SOD/Catalase Mimetics to Mitigate Radiation Damage and Retain Normal Wound Healing Capabilities in Adult Mammals Exposed to Gamma and Neutron Radiation - CENTRII 08 Symposium, April 2008
• Extracellular Matrix-Derived Factors Promote Tissue Regeneration and Avert Scar Formation, April 2008 - Providence, RI
• A New Non-Proteolytic Method for Decellularizing Natural Bioskaffolds - Fifth Annual Regeneration Symposium Series, February 2008 - Phoenix, AZ
• The Role of Extracellular Matrix in Blastema Formation at a Wound or Amputated Digit Site of a Non-Regenerative Adult Mammal - Annual Tissue Regeneration Meeting, November 2007 - Jackson Hole, WY
• The Quartz Microbalance as a Novel Cell Based Biosensor - Distinguished Seminar Series, November 2007 - Boston, MA
• Can Extracellular Matrix-Derived Factors Stimulate Blastema Formation at a Proximal Digit Amputation Site of a Non-Regenerative Adult Mammal?, September 2007 - Philadelphia, PA
• Extracellular Matrix-Derived Factors Promote Tissue Regeneration and Avert Scar Formation, March 2007 - New York, NY
• The Role of Extracellular Matrix in Tissue Regeneration, February 2007 - Washington, D.C.
• The Extracellular Matrix as a Depository of Regenerative Factors, September 2006 - Chicago, IL
• Limb Restoration Using Extracellular Matrix Derived Products - Restorative Injury Repair Meeting, May 2006 - Brooke Army Medical Center, San Antonio, TX
• Tissue Regenerative Factors Selectively Released from Cell Free Extracellular Matrix by Applied Electrical Potentials - International Electromagnetic Society Meeting, June 2005 - Dublin, Ireland
• The Wound Environment - International Accelerated Injury Repair Meeting, May 2005 - Arlington, Virginia
• New Methods of Wound Healing, April 2005 - Boston, MA
• New Methods of Nanodiagnosis and Nanotherapy of Human Disease: Breast Cancer and Wound Healing, October 2004 - Newton, MA
• Development of a Smart Bandage, February 2004 - Spencer, MA
• Development of a Smart Bandage, January 2004 - Waltham, MA
• Development of a Smart Bandage: Applying electrical potential to selectively release wound healing growth factors from cell free extracellular matrices, December 2003 - Boston, MA
• Principles of the Partnership: Assistance and Procurement, November 2003
• Development of a Smart Bandage, May 2003 - Westwood, MA
• The Use of Electrical Potential for the Release of Growth Factors from Extracellular Matrix - DARPA Annual Meeting, May 2003 - Orlando, FL
• Cell Biosensor Systems for Cancer Diagnosis, Prognosis, and Drug Testing, March 2003 - Wallingford, CT
• Welcome to the Federal Demonstration Partnership, phase IV, September 2002 - Washington, D.C.
• Biofilms Plus Cell BioSensor Systems, June 2002 - San Francisco, CA
• Human Cancer Cell Biosensor of Taxane Activities and Mechanisms, April 2001 - Princeton, New Jersey
• Development of Whole Cell Biosensors to Detect and Distinguish Chemotherapeutic Activities of Docetaxel and Paclitaxel - American Cancer Society Annual Meeting, December 2000 - Toronto, Canada
• NIH and Universities: Commonalities, Cooperation, and Constraints, March 2000 - Duke University, Durham, North Carolina
• How to Wow a Study Section: A Grantsmanship Lesson, November 1998 - Lowell, Massachusetts
• Effects of Ionizing Radiation on the Vasculature: Beyond Double Strand Breaks and Future Radiotherapeutics, August 1998 - Groton, Connecticut
• Oxidative Stress-induced Apoptosis - Role of Matrix Metalloproteinases, April 1998 - Louisville, Kentucky
• Matrix Metalloproteinases (MMPs) Produced by Irradiated Endothelial Cells - Radiation Research Society Meeting, May 1997 - Providence, Rhode Island
• Retinoids and Prostate Cancer - Prostate Cancer Retreat, January 1997 - Boston, Massachusetts
• The Radiobiology of the Vasculature and Angiogenesis, December 1996 - Boston, Massachusetts
• Anatomy of the Cell and How to Study It - Molecular and Cellular Radiation Oncology Course, April 1996 - Boston, Massachusetts
• The Ying and Yang of Cytokines - 44th Annual Meeting of the Radiation Research Society, April 1996 - Chicago, Illinois
• The Cytokines and Inhibitors Involved in Normal and Pathologic Angiogenesis - Frontiers in Biomedicine, December 1995 - Teterboro, New Jersey
• Matrix Metalloproteinases (MMPs) Produced by Irradiated Endothelial Cells - International Congress of Radiation Research, August 1995 - Wurzburg, Germany
• Tempol Protects Against Impairment of the Endothelial Cell Wound Healing Response by Ionizing Radiation - Ninth Conference of Chemical Modifiers of Cancer Treatment, August 1995 - Oxford, UK
• Radiation Effects on Capillary Endothelial Cells: Apoptosis, PAF - Like Molecules and Defective Wound Healing", June 1995 - Durham, North Carolina
• Monoclonal Antibodies, March 1995 - Lowell, Massachusetts
• Angiogenesis, November 1994 - Boston, Massachusetts
• The Modulating Effects of Retinoids on Endothelioma Cell Growth, Phenotype, and Tumorigenicity - Diet and Cancer: Molecular Mechanisms of Interactions, September 1994 - Washington, D.C.
• Effects of Ionizing Radiation on Vasculature, May 1994 - Boston, Massachusetts
• Effects of Ionizing Radiation on the Vasculature, December 1993 - Holland

Selected Intellectual Property

• Patent - Braunhut, S.J."Biofilms plus whole cell biosensor detection and diagnosis," 60/451, 583
• Patent - Braunhut, S.J."Drug testing and drug response detection using biosensors," 10/144, 193
• Patent - Braunhut, S.J."Novel acoustic wave (AW) sensing devices using live cells," 0813.204
• Patent - Marx, K.A., Braunhut, S.J., Zhou, T., Rugh, A."Selective whole cell quartz crystal microbalance biosensors," US: 435/5 International: 61F 007/00
• Patent - Braunhut, S.J."Synthesis of novel water-soluble oligo/polycatechins," 0813.2009
• Patent - Braunhut, S.J."The Smart Bandage," 60/389, 825
• Patent - Handy, E.S., Ivkov, R., Ellis-Busby, D., Foreman, A., Braunhut, S.J., Gwost, D., Ardman, B."Thermotherapy via targeted delivery of nanoscale magnetic particles," US: 607/103 International: 61F 007/00
• Patent - Therrien, J.M., Braunhut, S.J., Marx, K.A., Wang, G., Vashist, M., Dewilde, A.H., Zhang, J., Sun, H., Dai, L., Liu, S."Acoustic wave sensing devices using live cells," 13/300,407 United States
• Patent - Bruno, F., Nagarajan, S., Samuelson, L., Braunhut, S.J., Kumar, J."Protection and mitigation of radiation induced cell death by novel semi-synthetic polycatechins,"
• Patent - Braunhut, S.J., Hechavarria, D., Kaplan, D., Levin, M."Sleeve for Stimulation of Tissue Regeneration," 2012/139873 Patent Cooperation Treaty
• Patent - Kumar, J., Bruno, F.F., Braunhut, S.J., Nagarajan, R., Samuelson, L.A., McIntosh, D., Foley, K."Sythesis of Oligo/Poly(Catechins) and Methods of Use," 8,143,308 B2 United States

Selected Contracts, Fellowships, Grants and Sponsored Research

• A human breast cancer cell biosensor of taxanes (1990), Grant - Aventis Pharmaceuticals
  Braunhut, S.J. (Principal)
• Centers for Medical Countermeasures Against Radiation Terrorism (CMCRT) (1990), Grant - NIH
  Moulder, J. (Principal), Braunhut, S.J. (Co-Principal), Tries, M.A. (Co-Principal)
• Control of the Microenvironmental Niche to Promote Epimorphic Regeneration in Amputated Digits (1990), Grant - Department of Defense
  Braunhut, S.J. (Principal)
• DC stimulated angiogenesis (1990), Grant - NIH
  Marx, K. (Principal), Braunhut, S.J. (Co-Principal)
• Development of a novel hyperthermia treatment for metastatic disease (1990), Grant - Triton BioSystems, Inc.
  Braunhut, S.J. (Principal)
• Development of a novel therapy for breast cancer (1990), Grant - Sensera, Inc.
  Braunhut, S.J. (Principal)
• Development of a novel therapy for breast cancer (1990), Grant - Triton BioSystems, Inc.
  Braunhut, S.J. (Principal)
• Development of novel radioprotectors (1990), Grant - Biomodels LLC
  Braunhut, S.J. (Principal)
• Development of the Smart Bandage (1990), Grant - Defense Advanced Research Projects Agency (DARPA)
  Braunhut, S.J. (Principal)
• Effects of retro-retinoids on mammary tumor growth (1990), Grant - American Institute for Cancer Research
  Braunhut, S.J. (Principal)
• Effects of retro-retinoids on tumor angiogenesis (1990), Grant - US Army Medical Research
  Braunhut, S.J. (Principal)
• Enzymatically Synthesized Novel Oligomeric Catechins for Breast Cancer Treatment (1990), Grant - US Army Medical Research
  Kumar, J. (Principal), Braunhut, S.J. (Co-Principal)
• Mechanism of action of antibody directed nanoparticles for treatment of Human head and neck cancer (1990), Grant - Aduro Biotech Inc.
  Braunhut, S.J. (Principal)
• Multi-Channel potentiostat (1990), Grant - DARPA
  Braunhut, S.J. (Principal)
• Nanomanufacturing of Multifunctional Sensors. The nanocanary-development of a portable cell based biosensor for detection of weaponized agents (1990), Grant - U.S. Army Research
  Mead, J. (Principal), Marx, K.A. (Co-Principal), Braunhut, S.J. (Co-Principal), Project 6, .
• Novel mechanisms of radiation sensitivity (1990), Grant - NIH (National Institutes of Health)
  Braunhut, S.J. (Principal)
• Novel synthetic catechins for anticancer applications (1990), Grant - US Environmental Protection Agency
  Subhalakshmi, ., Nagarajan, ., Braunhut, S.J. (Supporting), Kumar, J. (Supporting)
• Rotations in contemporary biology lab techniques (1990), Grant - NSF
  Skare, I. (Principal), Braunhut, S.J. (Co-Principal)
• Supraparamagnetic nanoparticles for the treatment of human cancers (1990), Grant - Department of Defense
  Braunhut, S.J. (Principal)
• The influence of Vitamin A on regression of malignant tumors (1990), Grant - American Institute for Cancer Research
  Braunhut, S.J. (Principal)
• The modulating effects of Vitamin A on tumor growth (1990), Grant - American Institute for Cancer Research
  Braunhut, S.J. (Principal)
• The use of compression molded composite materials for selective cell attachment and growth (1990), Grant - Massachusetts Technology Council (MTC)
  Barry, C. (Principal), Braunhut, S.J. (Co-Principal)
• Innovative Biomarkers to Predict Radiation Lung Injury (2012), Grant - NIH
  Braunhut, S.J. (Principal)
• Developing Nanocanary Technologies Commercialization business plan for a start-up company (), Grant - MTC
  Braunhut, S.J. (Principal)
• Development of a 1st Generation Acoustic Wave Biosensor Platform (), Grant - CVIP
  Therrien, J.M. (Principal), Braunhut, S.J. (Principal), Marx, K.A. (Principal)
• Facilitate Relicensing Efforts, Maintain Reactor Operations, and Expand Research and Educational Capabilities (2011), Grant - DOE
  Tries, M.A. (Principal), Braunhut, S.J. (Co-Principal), Therrien, J.M. (Co-Principal)
• NSF Nanoscale Science and Engineering Center for High-rate Nanomanufacturing (2011), Grant - NSF
  Braunhut, S.J. (Principal), Therrien, J.M. (Principal)
• Mammalian limb regeneration, Phase 1 (2006), Grant - DARPA
  Braunhut, S.J. (Principal)

Research Currently in Progress

• Naturally occurring phytochemical such as ingredients found in turmeric Curcumin and green tea (epicatechins)

  The applications of these materials and their derivatives as antitumor agents and radiation protection or mitigation agents is being pursued in collaboration with Prof. Braunhut (Biology), Prof. Mark Tries (Physics) and Prof. David Kaplan (Tufts).
  Kumar, J., Braunhut, S.J., Tries, M.A., Kaplan, D.

• Naturally occurring phytochemical such as ingredients found in turmeric Curcumin and green tea (epicatechins).

  The applications of these materials and their derivatives as antitumor agents and radiation protection or mitigation agents is being pursued in collaboration with Prof. Braunhut, Prof. Mark Tries and Prof. David Kaplan.
  Kumar, J., Braunhut, S.J., Tries, M.A., Kaplan, D.