Dongming Xie

Expertise

Biochemical Engineering, Bioprocess Modeling and Control, Metabolic Engineering, Fermentation Technology, Industrial Biotechnology

Research Interests

Metabolic Engineering; Biochemical Engineering; Biomanufacturing; Bioprocess Modeling, Optimization, and Control.

1. Microbial Biomanufacturing platform: Engineering bacteria and yeast cells; Cellular and metabolic engineering; Products: omega-3 fatty acids; carotenoids, wax esters; Bioprocess and bioreactor engineering; Bioenergy – continuous manufacturing of biofuels.
2. Biomanufacturing of pharmaceuticals: Integrated continuous biomanufacturing.
3. Bioprocess and Bioreaction Modeling: Bioprocess modeling, optimization, and control; Application of AI (Artificial Intelligence) in Bioprocesses; Computational Fluid Dynamics (CFD) of Bioreactors.
4. Biodegradation and Bioconversion of Plastic Wastes: Enzymatic Degradation of PET plastics; Engineered bacteria to produce enzymes; Design of new enzymatic reaction system.

Education

• Postdoc, (2006), Michigan State University
• Postdoc, (2002), Tsinghua University
• Ph D: Biochemical Engineering, (2000), Chinese Academy of Sciences - Beijing, China
  Dissertation/Thesis Title: Dynamic modeling and optimal control strategy for glycerol production by fermentation
• BS: Chemical Engineering, (1992), East China University of Science & Technology - Shanghai, China
  Dissertation/Thesis Title: Nozzle optimization for coal-water gasification

Biosketch

Dongming Xie is an associate professor in Chemical Engineering. His research focuses on metabolic engineering, bioprocess engineering, and continuous biomanufacturing. Prior to joining UML in 2016, Dr. Xie was a principal scientist at DuPont during 2006-2016, where he led the fermentation engineering team to commercialize the omega-3 project, which brought the company two new commercial products.

Selected Awards and Honors

• Teaching Excellence Award (2020), Teaching - University of Massachusetts Lowell
• DuPont Bolton/Carothers Innovative Science Award (2014), Scholarship/Research
• DuPont Accomplishment Award (2008), Scholarship/Research
• 2001 Tsinghua University Distinguished Postdoc Award (2002), Scholarship/Research

Selected Publications

• Liu, N., Liu, B., Wang, G., Soong, Y., Tao, Y., Liu, W., Xie, D. (2020). Lycopene Production from Glucose, Fatty acid and Waste Cooking Oil by Metabolically Engineered Escherichia coli. Biochemical Engineering Journal, 155 107488.
• Soong, Y., Liu, N., Yoon, S., Lawton, C., Xie, D. (2019). Cellular and Metabolic Engineering of Oleaginous Yeast Yarrowia lipolytica for Bioconversion of Hydrophobic Substrates into High-Value Products. . Engineering in Life Science, 19 423-443.
• Xie, D., Soong, Y., N, L., Qin, J., Chen, S., Keats, J., Mirzaee, I., Lawton, C. (2018). A new biomanufacturing platform for bioconversion of plant oils into high-value products. Adv. Biochem. Biotechnol., 2018 ABIO-149.
• Xie, D. (2017). Integrating cellular and bioprocess engineering in the nonconventional yeast Yarrowia lipolytica for biodiesel production: A review. Frontiers in Bioengineering and Biotechnology, 5 65.
• Xie, D., Miller, E., Tyreus, B., Jackson, E., Zhu, Q. (2017). Sustainable Production of Omega-3 Eicosapentaenoic Acid by Fermentation of Metabolically Engineered Yarrowia lipolytica. In book: Quality Living Through Chemurgy and Green Chemistry (Ed. Lau P.C.K.), pp.17-33. (pp. pp.17-33).
• Xie, D., Miller, E., Sharpe, P., Jackson, E., Zhu, Q. (2016). Omega-3 production by fermentation of Yarrowia lipolytica: From fed-batch to continuous. Biotechnology and Bioengineering, 114 798-812.
• Xie, D., Jackson, E.N., Zhu, Q. (2015). Sustainable Source of Omega-3 Eicosapentaenoic acid from Metabolically Engineered Yarrowia lipolytica: From Fundamental Research to Commercial Production. Applied Microbiology and Biotechnology, 99 1599-1610.
• Xue, Z., Sharpe, P.L., Hong, S.P., Yadav, N.S., Xie, D., Short, D.R., Damude, H.G., Rupert, R.A., Seip, J.E., Wang, J., Pollak, D.W., Bostick, M., Bosack, M., Macool, D., Hollerbach, D., Zhang, H., Arcilla, D., Bledsoe, S., Croker , K., McCord, E., Tyreus, B., Jackson, E.N., Zhu, Q. (2013). Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. Nature Biotechnology, 31 734-740.

Selected Intellectual Property

• Patent - Xie, D."MICROBIAL CONVERSION OF OILS AND FATS TO LIPID-DERIVED HIGH-VALUE PRODUCTS," EFS ID: 39676601; Application No. 63037151. United States

Selected Contracts, Fellowships, Grants and Sponsored Research

• Collaborative Research: A New Yeast Biomanufacturing Platform for Making High-Value Products from Oils and Fats (2020), Grant - NSF/CBE
  Xie, D. (Principal)
• Bioconversion of Heterogeneous Polyester Wastes to High-Value Chemical Products (2020), Grant - DOE/EERE
  Xie, D. (Co-Principal)
• Biomanufacturing Capital: Integrated Continuous Biopharmaceutical Manufacturing Utilizing Robust In-Line NIR Mediated Control (2019), Grant - Massachusetts Life Science Center
  Xie, D. (Co-Principal)
• Optical Redox Probe for Continuous Metabolic Monitoring during Natural Products Bioprocessing (2020), Grant - NIH/SBIR (Phase I)
  Xie, D. (Co-Principal)
• High levels of protein production by engineered E. coli (2020), Sponsored Research - Biotechnology Industry Sponsor #2
  Xie, D. (Principal)
• Continuous Biomanufacturing: Increased Biosynthesis from Engineered Cells (2019), Grant - UML-WPI Seed Grant
  Xie, D. (Principal)
• Control and estimation of glycosylation profile via media supplementation based on intracellular metabolic models in mammalian cell cultures (2017), Grant - NSF/CBE
  Xie, D. (Co-Principal)
• Production of probiotics under optimized fermentation conditions (2018), Sponsored Research - Biotechnology Industry Sponsor #1
  Xie, D. (Principal)