03/22/2025
By Kwok Fan Chow

The Kennedy College of Science, Department of Chemistry, invites you to attend a Ph.D. Dissertation defense by Mubarak Ayinla titled, “Rational Design of Multifunctional Complex Molecular Architectures via Dynamic Covalent Chemistry.”

Location: Lydon, Room 110
Date: Friday, April 4, 2025
Time: 2 p.m.

Committee Chair:
Professor Olof Ramström, Department of Chemistry, UMass Lowell

Committee Members:
Professor Mingdi Yan, Department of Chemistry, UMass Lowell
Professor Marina Ruths, Department of Chemistry, UMass Lowell
Professor Lawrence Wolf, Department of Chemistry, UMass Lowell

Abstract:

Dynamic covalent chemistry offers a transformative platform for the rational design and synthesis of structurally intricate materials with broad applications in drug discovery, biotechnology, molecular separation and storage technology. By applying this powerful approach, this thesis investigates the underutilized potential of the nitroaldol (Henry) reaction and the versatility of imine (Schiff base) formation to build complex molecular architectures.

Traditionally limited to small molecule synthesis, we have reimagined the century-old nitroaldol reaction as an enabling tool for macromolecular assembly. By exploring reaction conditions, monomer selection and thermodynamic equilibria, this research provides more insights into the design principles governing nitroaldol-mediated polymerization and macrocyclization.

Concurrently we explored a modulation-controlled strategy for Schiff base chemistry, taking advantage of its reversibility to construct advanced frameworks. Through parameter optimization, we gained precise control over the material structure and functionality to create adaptive materials tailored for specific applications. By tapping into these complementary dynamic covalent reactions, we have synthesized a diverse range of multifunctional architectures that include macrocycles, linear and network dynamic covalent polymers (dynamers), and reticulated frameworks.

Consequently, this work offers a comprehensive approach for the development of dynamic covalent systems with complex architectures while simultaneously expanding the library and diversity of synthetic methods for multifunctional materials.

All interested students and faculty members are invited to attend.