11/25/2024
By Amanda Vozzo

Jefferson C. Frisbee of Western University, London, Ontario, will give a talk, “System Level Failure in Metabolic Disease: Emergence of Complex Microvascular Behaviors as Predictors of Health Outcomes."

Date: Monday, Dec. 9
Time: 4 to 5 p.m.
Location: Olsen 503

Abstract: The study of vascular disease has been largely focused on single indices of vascular health, such as reactivity, wall mechanics and imaging-based assessments of arterial blood flow. While helpful, these measures have been somewhat coarse in predicting functional and health outcomes. In our preclinical model for metabolic disease, we will present a novel, integrated system approach to understanding microvascular health. This approach is fundamentally based on arteriolar hemodynamics and the fractal geometry of the microcirculation and can be a much stronger predictor of functional outcomes and the emergence of complex pathologies with chronic metabolic disease. The concluding section of this discussion will address our innovative approaches to microvascular network biosimulation and our efforts to bring models to life through advanced analytics and the integration of high spatial and temporal resolution databases on vascular health and dysfunction.

Bio: Jefferson Frisbee completed his PhD in Biophysics (Physiology) from the University of Guelph. Following postdoctoral fellowships at the University of Washington (Cardiovascular Bioengineering) and the Medical College of Wisconsin (Microvascular Physiology), and after several years as an Assistant Professor at MCW, Frisbee was recruited to the West Virginia University Health Sciences Center in the Department of Physiology and Pharmacology. Subsequent to the establishment and expansion of his research program at WVU, Frisbee was named as director of the Center for Cardiovascular and Respiratory Sciences and for the Clinical and Translational Sciences Doctoral Program. He also serves as the editor in chief of the journal Microcirculation and has extensive experience on study sections for the National Institutes of Health, the American Heart Association and the American Diabetes Association.