Garry Handelman, Department Chair, Professor, Biomedical and Nutritional Sciences, HEROES, UMass Lowell Center for Population Health

Garry J Handelman

Professor Emeritus

College
Zuckerberg College of Health Sciences
Department
Biomedical & Nutritional Sciences
Phone
(978) 934-4503
Email
Garry_Handelman@uml.edu

Expertise

Nutritional Sciences

Research Interests

Nutritional Sciences

My research program has focused on the nature of pathological changes that occur in long-term renal failure, with a goal of better understanding how to care for patients on dialysis. Four million Americans have impaired renal function, and 300,000 Americans require permanent dialysis treatment to replace lost renal function. We have studied oxidant stress (breath ethane, isoprostanes, and inflammatory markers) and the influence of dietary antioxidant supplementation (vitamin E and selenium). We are studying vitamin C levels in patients on dialysis, since many patients have very low plasma vitamin C, and are seeking to determine if these patients would benefit from interventions to raise their plasma vitamin C levels. We are also studying the biology of anemia in these patients, and are seeking better ways of administering iron to avoid chronic anemia in dialysis. Because 40 percent of all renal failure is linked to obesity and diabetes, and another 30 percent to hypertension, I have worked with other faculty at Lowell and elsewhere to better understand the prevention of diabetes and hypertension through diet and exercise. This is a major developing focus of my research, since these diseases are highly preventable through life style modifications. Current research questions include better diets that do not elevate blood glucose levels (low-glycemic diets), since these diets may lead to less obesity. The carotenoids found in the egg yolk (lutein and zeaxanthin) are also found at the center of the retina, and these carotenoids may prevent age-related diseases in the retina. My laboratory is investigating strategies, involving egg consumption and other interventions, to raise the level of the carotenoids in the retina.

Education

  • Ph D: Biochemistry, (1991), Tufts University - Boston, MA
  • BA: Biology, (1986), University of California Santa Cruz - Santa Cruz, CA

Selected Publications

  • Tao, X., Thijssen, S., Kotanko, P., Ho, C., Henrie, M., Stroup, E., Handelman, G.J. (2016). Improved dialytic removal of protein-bound uraemic toxins with use of albumin binding competitors: an in vitro human whole blood study. Scientific Reports, 23389.
  • Liu, Y., Weisberg, L.S., Langman, C.B., Logan, A., Hunter, K., Prasad, D., Avila, J., Venkatchalam, T., Berns, J.S., Handelman, G.J., Sirover, W.D. (2016). Plasma oxalate levels in prevalent hemodialysis patients and potential implications for ascorbic acid supplementation. Clinical Biochemistry, 49 1133 - 1139.
  • Rozati, M., Barnett, J., Wu, D., Handelman, G.J., Dallal, G., Saltzman, E., Wilson, T.A., Li, L., Wang, J., Marcos, A. (2015). Cardiometabolic and Immunological Impacts of Extra Virgin Olive Oil Consumption in Overweight and Obese Older Adults: A Randomized Controlled Trial. The FASEB Journal, 29(1 Supplement) 252.6.
  • Tao, X., Thijssen, S., Levin, N., Kotanko, P., Handelman, G.J. (2015). Enhanced Indoxyl Sulfate Dialyzer Clearance with the Use of Binding Competitors. Blood purification, 39(4) 323-330.
  • Sirover, W.D., Liu, Y., Logan, A., Hunter, K., Benz, R.L., Prasad, D., Avila, J., Venkatchalam, T., Weisberg, L.S., Handelman, G.J. (2015). Plasma ascorbic acid concentrations in prevalent patients with end-stage renal disease on hemodialysis. Journal Of Renal Nutrition: The Official Journal Of The Council On Renal Nutrition Of The National Kidney Foundation, 25(3) 292-300.
  • Tao, X., Hoenich, N., Handelman, S.K., Levin, N.W., Kotanko, P., Handelman, G.J. (2014). Transfer of low-molecular weight single-stranded DNA through the membrane of a high-flux dialyzer. The International journal of artificial organs, 37(7) 529-538.
  • Sirover, W.D., Liu, Y., Logan, A., Hunter, K., Benz, R.L., , Avila, J., Venkatchalam, T., Weisberg, L.S., Handelman, G.J. (2014). Plasma Ascorbic Acid Concentrations in Prevalent Patients With End-Stage Renal Disease on Hemodialysis. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
  • Tao, X., Hoenich, N., Handelman, S.K., Levin, N.W., Kotanko, P., Handelman, G.J. (2014). Transfer of low-molecular weight single-stranded DNA through the membrane of a high-flux dialyzer. The International journal of artificial organs, 37(7) 529-38.
  • Handelman, G.J. (2014). Reply: Blood Purification (37:1 pp. 47). Blood Purification
  • Handelman, G.J., Kotanko, P., Cisternas, M.G., Hoenich, N., Usvyat, L., Kuhlmann, M., Levin, N.W. (2013). Hospitalization and mortality in hemodialysis patients: association with hemoglobin variability. Blood purification, 35(4) 247-57.
  • Carter, M.J., Callegari, J.G., Kilonzo, K.G., Yeates, K.E., Handelman, G.J., Finkelstein, F.O., Kotanko, P., Levin, N.W. (2012). Peritoneal dialysis for acute kidney injury in sub-Saharan Africa: challenges faced and lessons learned at Kilimanjaro Christian Medical Centre. Kidney international, 81(4) 331-3.
  • Handelman, G.J., Kotanko, P., Levin, N.W. (2007). Mechanisms of hypertension [9]. New England Journal of Medicine, 357(8) 828.
  • Handelman, G.J. (2007). Newer strategies for anemia prevention in hemodialysis. International Journal of Artificial Organs, 30(11) 1014-1019.
  • Levin, N.W., Handelman, G.J., Coresh, J., Port, F.K., Kaysen, G.A. (2007). Reverse epidemiology: A confusing, confounding, and inaccurate term. Seminars in dialysis, 20(6) 586-592.
  • Handelman, G.J. (2007). Vitamin C deficiency in dialysis patients - Are we perceiving the tip of an iceberg? Nephrology Dialysis Transplantation, 22(2) 328-331.
  • Wenzel, A.J., Gerweck, C., Barbato, D., Nicolosi, R.J., Handelman, G.J., Curran-Celentano, J. (2006). A 12-Wk egg intervention increases serum zeaxanthin and macular pigment optical density in women. Journal of Nutrition, 136(10) 2568-2573.
  • Gotch, F., Kotanko, P., Handelman, G.J., Levin, N. (2006). A kinetic model of calcium mass balance during dialysis therapy. Blood purification, 25(1) 139-149.
  • Goodrow, E.F., Wilson, T.A., Houde, S.C., Vishwanathan, R., Scollin, P.A., Handelman, G.J., Nicolosi, R.J. (2006). Consumption of one egg per day increases serum lutein and zeaxanthin concentrations in older adults without altering serum lipid and lipoprotein cholesterol concentrations. Journal of Nutrition, 136(10) 2519-2524.
  • Handelman, G.J. (2006). Vitamin C neglect in hemodialysis: Sailing between Scylla and Charybdis. Blood purification, 25(1) 58-61.
  • Goodrow, E.F., Wilson, T.A., Houde, S., Vishwanathan, R., Scollin, P.A., Handelman, G.J., Nicolosi, R.J. (2006). Consumption of One Egg Per Day Increases Serum Lutein and Zeaxanthin Concentrations in Older Adults without Altering Serum Lipid and Lipoprotein Cholesterol Concentrations. Journal of Nutrition, 136(10) 2519.
  • Van Der Sande, F.M., Rosales, L.M., Brener, Z., Kooman, J.P., Kuhlmann, M., Handelman, G.J., Greenwood, R.N., Carter, M., Schneditz, D., Leunissen, K.M., Levin, N.W. (2005). Effect of ultrafiltration on thermal variables, skin temperature, skin blood flow, and energy expenditure during ultrapure hemodialysis. Journal of the American Society of Nephrology, 16(6) 1824-1831.
  • Wilson, T.A., Nicolosi, R.J., Handelman, G.J., Yoganathan, S., Kotyla, T., Orthoefer, F., Binford, P. (2004). Comparative effects of emu and olive oil on aortic early atherosclerosis and associated risk factors in hypercholesterolemic hamsters. Nutrition Research, 24(6) 395-406.
  • Nicolosi, R.J., Woolfrey, B., Wilson, T.A., Scollin, P., Handelman, G.J., Fisher, R. (2004). Decreased aortic early atherosclerosis and associated risk factors in hypercholesterolemic hamsters fed a high- or mid-oleic acid oil compared to a high-linoleic acid oil. Journal of Nutritional Biochemistry, 15(9) 540-547.
  • Alexaki, A., Wilson, T.A., Atallah, M.T., Handelman, G.J., Nicolosi, R.J. (2004). Hamsters Fed Diets High in Saturated Fat Have Increased Cholesterol Accumulation and Cytokine Production in the Aortic Arch Compared with Cholesterol-Fed Hamsters with Moderately Elevated Plasma Non-HDL Cholesterol Concentrations. Journal of Nutrition, 134(2) 410-415.
  • Yoganathan, S., Nicolosi, R., Wilson, T., Handelman, G.J., Scollin, P., Tao, R., Binford, P., Orthoefer, F. (2003). Antagonism of croton oil inflammation by topical emu oil in CD-1 mice. Lipids, 38(6) 603-607.
  • Handelman, G.J., Rosales, L.M., Barbato, D., Luscher, J., Adhikarla, R., Nicolosi, R.J., Finkelstein, F.O., Ronco, C., Kaysen, G.A., Hoenich, N.A., Levin, N.W. (2003). Breath ethane in dialysis patients and control subjects. Free Radical Biology and Medicine, 35(1) 17-23.
  • Handelman, G.J. (2003). Current studies on oxidant stress in dialysis. Blood purification, 21(1) 46-50.
  • Handelman, G.J. (2003). Efforts to Determine the Role of Oxidant Stress in Dialysis Outcomes. Seminars in dialysis, 16(6) 488-491.
  • Saran, R., Novak, J.E., Desai, A., Abdulhayoglu, E., Warren, J.S., Bustami, R., Handelman, G.J., Barbato, D., Weitzel, W., D'Alecy, L.G., Rajagopalan, S. (2003). Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): A pilot study. Nephrology Dialysis Transplantation, 18(11) 2415-2420.
  • Nicolosi, R.J., Wilson, T.A., Handelman, G.J., Foxall, T., Keaney Jr, J.F., Vita, J.A. (2002). Decreased aortic early atherosclerosis in hypercholesterolemic hamsters fed oleic acid-rich TriSun oil compared to linoleic acid-rich sunflower oil. Journal of Nutritional Biochemistry, 13(7) 392-402.
  • Nicolosi, R.J., Wilson, T.A., Lawton, C., Handelman, G.J. (2001). Dietary effects on cardiovascular disease risk factors: Beyond saturated fatty acids and cholesterol. Journal of the American College of Nutrition, 20(5 SUPPL.) 421-427.
  • Handelman, G.J., Walter, M.F., Adhikarla, R., Gross, J., Dallal, G.E., Levin, N.W., Blumberg, J.B. (2001). Elevated plasma F2-isoprostanes in patients on long-term hemodialysis. Kidney international, 59(5) 1960-1966.
  • Spittle, M.A., Hoenich, N.A., Handelman, G.J., Adhikarla, R., Homel, P., Levin, N.W. (2001). Oxidative stress and inflammation in hemodialysis patients. American Journal of Kidney Diseases, 38(6) 1408-1413.
  • Handelman, G.J. (2001). The evolving role of carotenoids in human biochemistry. Nutrition, 17(10) 818-822.
  • Handelman, G.J. (2000). Evaluation of oxidant stress in dialysis patients. Blood purification, 18(4) 343-349.
  • Knutson, M.D., Handelman, G.J., Viteri, F.E. (2000). Methods for measuring ethane and pentane in expired air from rats and humans. Free Radical Biology and Medicine, 28(4) 514-519.
  • Nightingale, Z.D., Lancha Jr., A.H., Handelman, S.K., Dolnikowski, G.G., Busse, S.C., Dratz, E.A., Blumberg, J.B., Handelman, G.J. (2000). Relative reactivity of lysine and other peptide-bound amino acids to oxidation by hypochlorite. Free Radical Biology and Medicine, 29(5) 425-433.
  • Walter, M.F., Blumberg, J.B., Dolnikowski, G.G., Handelman, G.J. (2000). Streamlined F2-isoprostane analysis in plasma and urine with high- performance liquid chromatography and gas chromatography/mass spectroscopy. Analytical Biochemistry, 280(1) 73-79.
  • Handelman, G.J., Cao, G., Walter, M.F., Nightingale, Z.D., Paul, G.L., Prior, R.L., Blumberg, J.B. (1999). Antioxidant capacity of oat (Avena sativa L.) extracts. 1. Inhibition of low-density lipoprotein oxidation and oxygen radical absorbance capacity. Journal of Agricultural and Food Chemistry, 47(12) 4888-4893.
  • Wu, D., Meydani, M., Leka, L.S., Nightingale, Z., Handelman, G.J., Blumberg, J.B., Meydani, S.N. (1999). Effect of dietary supplementation with black currant seed oil or the immune response of healthy elderly subjects. American Journal of Clinical Nutrition, 70(4) 536-543.
  • Handelman, G.J., Nightingale, Z.D., Lichtenstein, A.H., Schaefer, E.J., Blumberg, J.B. (1999). Lutein and zeaxanthin concentrations in plasma after dietary supplementation with egg yolk. American Journal of Clinical Nutrition, 70(2) 247-251.
  • Nightingale, Z.D., Blumberg, J.B., Handelman, G.J. (1999). Purification of fatty acid methyl esters by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications, 732(2) 495-500.
  • Handelman, G.J., Nightingale, Z.D., Dolnikowski, G.G., Blumberg, J.B. (1998). Formation of carbonyls during attack on insulin by submolar amounts of hypochlorite. Analytical Biochemistry, 258(2) 339-348.
  • Kilic, F., Handelman, G.J., Traber, K., Tsang, K., Packer, L., Trevithick, J.R. (1998). Modelling cortical cataractogenesis XX. In vitro effect of -lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis. Biochemistry and molecular biology international, 46(3) 585-595.
  • Halpner, A., Belmont, C., Handelman, G.J., Blumberg, J.B. (1998). Oxidant-induced loss of vitamin C and vitamin E in primary rat hepatocytes. FASEB Journal, 12(5).
  • Halpner, A.D., Handelman, G.J., Harris, J.M., Belmont, C.A., Blumberg, J.B. (1998). Protection by vitamin C of loss of vitamin E in cultured rat hepatocytes. Archives of Biochemistry and Biophysics, 359(2) 305-309.
  • Halpner, A.D., Handelman, G.J., Belmont, C.A., Harris, J.M., Blumberg, J.B. (1998). Rapid communication: Protection by vitamin C of oxidant-induced loss of vitamin E in rat hepatocytes. Journal of Nutritional Biochemistry, 9(6) 355-359.
  • Obin, M., Shang, F., Gong, X., Handelman, G.J., Blumberg, J., Taylor, A. (1998). Redox regulation of ubiquitin-conjugating enzymes: Mechanistic insights using the thiol-specific oxidant diamide. FASEB Journal, 12(7) 561-569.
  • Haskell, M.J., Handelman, G.J., Peerson, J.M., Jones, A.D., Rabbi, M.A., Awal, M.A., Wahed, M.A., Mahalanabis, D., Brown, K.H. (1997). Assessment of vitamin A status by the deuterated-retinol-dilution technique and comparison with hepatic vitamin a concentration in Bangladeshi surgical patients. American Journal of Clinical Nutrition, 66(1) 67-74.
  • Haskell, M.J., Handelman, G.J., Islam, M.A., Jones, A.D., Peerson, J.M., Wahed, M.A., Mahalanabis, D., Brown, K.H. (1997). Comparison of plasma kinetics of an oral dose of tetra-deuterated retinyl acetate (TDRA) in human volunteers with estimated low or high total body stores of vitamin A. FASEB Journal, 11(3).
  • Haramaki, N., Han, D., Handelman, G.J., Tritschler, H.J., Packer, L. (1997). Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of -lipoic acid. Free Radical Biology and Medicine, 22(3) 535-542.
  • Handelman, G.J. (1997). High-dose vitamin supplements for cigarette smokers: Caution is indicated. Nutrition reviews, 55(10) 369-370.
  • Nakagawa, K., Kang, S.D., Park, D.K., Handelman, G.J., Miyazawa, T. (1997). Inhibition by -carotene and astaxanthin of NADPH-dependent microsomal phospholipid peroxidation. Journal of nutritional science and vitaminology, 43(3) 345-355.
  • Han, D., Handelman, G.J., Marcocci, L., Sen, C.K., Roy, S., Kobuchi, H., Tritschler, H.J., Floh�, L., Packer, L. (1997). Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. BioFactors, 6(3) 321-338.
  • Lodge, J.K., Youn, H.D., Handelman, G.J., Konishi, T., Matsugo, S., Mathur, V.V., Packer, L. (1997). Natural sources of lipoic acid: Determination of lipoyllysine released from protease-digested tissues by high performance liquid chromatography incorporating electrochemical detection. Journal of Applied Nutrition, 49(1-2) 3-11.
  • Taylor, A., Jacques, P.F., Nowell, T., Perrone, G., Blumberg, J., Handelman, G.J., Jozwiak, B., Nadler, D. (1997). Vitamin C in human and guinea pig aqueous, lens and plasma in relation to intake. Current eye research, 16(9) 857-864.
  • Mayne, S.T., Handelman, G.J., Beecher, G. (1996). -carotene and lung cancer promotion in heavy smokers - A plausible relationship? Journal of the National Cancer Institute, 88(21) 1513-1515.
  • Konishi, T., Handelman, G.J., Matsugo, S., Mathur, V.V., Tritschler, H.J., Packer, L. (1996). Amplified determination of lipoyl groups by lipoamide dehydrogenase in the presence of oxidized glutathione. Biochemistry and molecular biology international, 38(6) 1155-1161.
  • Haskell, M.J., Handelman, G.J., Jones, A.D., Peerson, J.M., Rabbi, A., Awal, M.A., Wahed, M.A., Mahalanabis, D., Brown, K.H. (1996). Comparison of hepatic vitamin a stores estimated by the deuterated retinol dilution technique or by analysis of hepatic biopsy specimens in bangladeshi surgical patients. FASEB Journal, 10(3).
  • Handelman, G.J., Packer, L., Cross, C.E. (1996). Destruction of tocopherols, carotenoids, and retinol in human plasma by cigarette smoke. American Journal of Clinical Nutrition, 63(4) 559-565.
  • Han, D., Handelman, G.J., Packer, L. (1995). Analysis of reduced and oxidized lipoic acid in biological samples by high-performance liquid chromatography. Methods in enzymology, 251 315-325.
  • Eiserich, J.P., Van der Vliet, A., Handelman, G.J., Halliwell, B., Cross, C.E. (1995). Dietary antioxidants and cigarette smoke-induced biomolecular damage: A complex interaction. American Journal of Clinical Nutrition, 62(6 SUPPL.) 1490-1500.
  • Pick, U., Haramaki, N., Constantinescu, A., Handelman, G.J., Tritschler, H.J., Packer, L. (1995). Glutathione reductase and lipoamide dehydrogenase have opposite stereospecificities for -lipoic acid enantiomers. Biochemical and biophysical research communications, 206(2) 724-730.
  • Kilic, F., Handelman, G.J., Serbinova, E., Packer, L., Trevithick, J.R. (1995). Modelling cortical cataractogenesis 17: In vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis. Biochemistry and molecular biology international, 37(2) 361-370.
  • Constantinescu, A., Pick, U., Handelman, G.J., Haramaki, N., Han, D., Podda, M., Tritschler, H.J., Packer, L. (1995). Reduction and transport of lipoic acid by human erythrocytes. Biochemical pharmacology, 50(2) 253-261.
  • Handelman, G.J., Han, D., Tritschler, H., Packer, L. (1994). -Lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium. Biochemical pharmacology, 47(10) 1725-1730.
  • Handelman, G.J., Epstein, W.L., Peerson, J., Spiegelman, D., Machlin, L.J., Dratz, E.A. (1994). Human adipose -tocopherol and -tocopherol kinetics during and after 1 y of -tocopherol supplementation. American Journal of Clinical Nutrition, 59(5) 1025-1032.
  • Katz, M.L., Christianson, J.S., Gao, C.L., Handelman, G.J. (1994). Iron-induced fluorescence in the retina: Dependence on vitamin A. Investigative Ophthalmology and Visual Science, 35(10) 3613-3624.
  • Handelman, G.J., Haskell, M.J., Jones, A.D., Clifford, A.J. (1993). An improved protocol for determining ratios of retinol-d4 to retinol isolated from human plasma. Analytical Chemistry, 65(15) 2024-2028.
  • Handelman, G.J., Frankel, E.N., Fenz, R., German, J.B. (1993). Chemical changes during the early phase of in vitro oxidative damage to human LDL. Biochemistry and molecular biology international, 31(4) 777-788.
  • Meydani, M., Evans, W.J., Handelman, G.J., Biddle, L., Fielding, R.A., Meydani, S.N., Burrill, J., Fiatarone, M.A., Blumberg, J.B., Cannon, J.G. (1993). Protective effect of vitamin E on exercise-induced oxidative damage in young and older adults. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 264(5 33-5) 0-0.
  • Meydani, M., Evans, W., Handelman, G.J., Fielding, R.A., Meydani, S.N., Fiatarone, M.A., Blumberg, J.B., Cannon, J.G. (1992). Antioxidant response to exercise-induced oxidative stress and protection by vitamin E. Annals of the New York Academy of Sciences, 669 363-364.
  • Handelman, G.J., Shen, B., Krinsky, N.I. (1992). High resolution analysis of carotenoids in human plasma by high-performance liquid chromatography. Methods in enzymology, 213 336-346.
  • Handelman, G.J., Snodderly, D.M., Adler, A.J., Russett, M.D., Dratz, E.A. (1992). Measurement of carotenoids in human and monkey retinas. Methods in enzymology, 213 220-230.
  • Handelman, G.J., Snodderly, D.M., Krinsky, N.I., Russett, M.D., Adler, A.J. (1991). Biological control of primate macular pigment: Biochemical and densitometric studies. Investigative Ophthalmology and Visual Science, 32(2) 257-267.
  • Handelman, G.J., Van Kuijk, F.J., Chatterjee, A., Krinsky, N.I. (1991). Characterization of products formed during the autoxidation of -carotene. Free Radical Biology and Medicine, 10(6) 427-437.
  • Snodderly, D.M., Handelman, G.J., Adler, A.J. (1991). Distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys. Investigative Ophthalmology and Visual Science, 32(2) 268-279.
  • Dugast, I.J., Papadopoulos, P., Zappone, E., Jones, C., Theriault, K., Handelman, G.J., Benarous, R., Drysdale, J.W. (1990). Identification of two human ferritin H genes on the short arm of chromosome 6. Genomics, 6(2) 204-211.
  • Krinsky, N.I., Russett, M.D., Handelman, G.J., Snodderly, D.M. (1990). Structural and geometrical isomers of carotenoids in human plasma. Journal of Nutrition, 120(12) 1654-1662.
  • Handelman, G.J., Kosted, P., Short, S., Dratz, E.A. (1989). Determination of selenium in human blood by high-performance liquid chromatography with fluorescence detection. Analytical Chemistry, 61(20) 2244-2249.
  • Crabtree, D.V., Adler, A.J., Handelman, G.J. (1989). Pentafluorobenzoic anhydride as a derivatizing agent for alcohols and hydroxy fatty acid methyl esters detected by electron capture in gas chromatography. Journal of chromatography, 466 251-270.
  • Handelman, G.J., Epstein, W.L., Machlin, L.J., Van Kuijk, F.J., Dratz, E.A. (1988). Biopsy method for human adipose with vitamin E and lipid measurements. Lipids, 23(6) 598-604.
  • Handelman, G.J., Dratz, E.A., Reay, C.C., Van Kuijk, F.J. (1988). Carotenoids in the human macula and whole retina. Investigative Ophthalmology and Visual Science, 29(6) 850-855.
  • van Kuijk, F.J., Sevanian, A., Handelman, G.J., Dratz, E.A. (1987). A new role for phospholipase A2: protection of membranes from lipid peroxidation damage. Trends in biochemical sciences, 12(C) 31-34.
  • Baker, H., Handelman, G.J., Short, S., Machlin, L.J., Bhagavan, H.N., Dratz, E.A., Frank, O. (1986). Comparison of plasma and tocopherol levels following chronic oral administration of either all-rac- -tocopheryl acetate or RRR- -tocopheryl acetate in normal adult male subjects. American Journal of Clinical Nutrition, 43(3) 382-387.
  • Handelman, G.J., Dratz, E.A. (1986). The role of antioxidants in the retina and retinal pigment epithelium and the nature of prooxidant-induced damage. Advances in Free Radical Biology and Medicine, 2(1) 1-89.
  • Van Kuijk, F.J., Handelman, G.J., Dratz, E.A. (1985). Consecutive action of phospholipase A2 and glutathione peroxidase is required for reduction of phospholipid hydroperoxides and provides a convenient method to determine peroxide values in membranes. Journal of Free Radicals in Biology and Medicine, 1(5-6) 421-427.
  • Handelman, G.J., Machlin, L.J., Fitch, K., Weiter, J.J., Dratz, E.A. (1985). Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans. Journal of Nutrition, 115(6) 807-813.
  • Van Kuijk, F.J., Handelman, G.J., Dratz, E.A. (1985). Rapid analysis of the major classes of retinoids by step gradient reversed-phase high-performance liquid chromatography using retinal (O-ethyl) oxime derivatives. Journal of chromatography, 348(1) 241-251.
  • Katz, M.L., Parker, K.R., Handelman, G.J., Bramel, T.L., Dratz, E.A. (1982). Effects of antioxidant nutrient deficiency on the retina and retinal pigment epithelium of albino rats: a light and electron microscopic study. Experimental eye research, 34(3) 339-369.
  • Katz, M.L., Parker, K.R., Handelman, G.J. (1982). Structural and biochemical effects of antioxidant nutrient deficiency on the rat retina and retinal pigment epithelium. Annals of the New York Academy of Sciences, Vol. 393 196-197.

Selected Presentations

  • Genetic and Nutritional Factors in Regulation of Apoptosis and Cancer Development, 2011 - Moshi, Tanzani
  • New Evidence for Importance of Vitamin C in Renal Anemia - International Conference on Renal Nutrition and Metabolism, 2010 - Lausanne, Switzerland
  • Role of Inflammation in Development of Heart Failure in Hemodialysis Patients - Conference on Cardiovascular Health in Renal Disease, 2009 - New York, NY
  • DNA fragments and inflammation in hemodialysis - International Conference on Dialysis, 2009 - Las Vegas, Nevada
  • Mitochondrial Bioenergetics and Efficiency of Oxidative Phosphorylation, 2008 - New York, NY
  • Vitamin C Supplements for Dialysis Patients: Risks are now Less, and Benefits Persist - International Conference on Dialysis, 2007 - Austin, Texas
  • Debate forum: Carnitine Supplements are not Justified in Dialysis Patients - International Conference on Dialysis, 2006 - Las Vegas, Nevada
  • Oxidant stress and dialysis: Further developments - International Conference on Dialysis, 2003 - Miami FL
  • Oxidant stress and inflammation in patients on hemodialysis - International Conference on Dialysis, 2000 - Tarpon Springs, FL
  • Use of oxidative stress markers in aging of the retina, 1999 - Boston, MA
  • Damage to macromolecules as markers of oxidative stress, 1998 - Boston, MA
  • Plasma carotenoids in response to different carotenoid-rich foods, 1998 - Boston, MA
  • Dietary antioxidants and aging, 1997 - Atlanta, GA
  • Antioxidant nutrient supplements and the aging process - American Oil Chemists Society, 1996 - Indianapolis, IN
  • Effects of dietary lipid on carotenoid absorption, 1996 - Boston, MA
  • Thiols, disulfides, and oxidant stress, 1996 - Nagoya, Japan
  • Vitamin deficiencies in the elderly, 1996 - Philadelphia, PA
  • Human carotenoid metabolism in health and disease, 1995 - Boston, MA
  • Gas chromatography/mass spectrometry of retinol derivatives in assessment of human vitamin A metabolism, 1993 - Gaithersburg, MD
  • HPLC determination of the vitamin A value of native foodstuffs, 1993 - Dhaka, Bangladesh
  • Vitamin A and carotenoids in human milk, 1993 - California
  • Human tissue carotenoids: separate effects of dietary intake and metabolism - Gordon Conference on Carotenoids, 1992 - Ventura, CA
  • Carotenoid oxidation products: potential role as anti-cancer metabolites, 1991 - California
  • Carotenoids in the retina: differences between Old World and New World primates, 1991 - Boston, MA

Selected Contracts, Fellowships, Grants and Sponsored Research

  • studies of dialysis patients (), Grant - Renal Research Institute, New York, NY
  • unrestricted gift (2012), Grant - Renal Research Institute, New York, NY
  • Assay of peptides released from bone digests (2013), -
    Handelman, G.J. (Principal)
  • Studies of Displacement of Compounds from Albumin in Plasmas Samples (2013), -
    Handelman, G.J. (Principal)
  • Assay for Iron as Ferric Pyrophosphate (2013), -
    Handelman, G.J. (Principal)
  • Particle size determination for floor cleaning particles (2013), -
    Handelman, G.J. (Principal)
  • Measurement of Canavanine and concanavlin A in samples (2013), -
    Handelman, G.J. (Principal)
  • Studies of Uremic Toxins (2010), -
    Handelman, G.J. (Principal)
  • Determining Vitamin C Intake Needed for Optimal Anemia Management in HD Patients (2011), -
    Handelman, G.J. (Principal)
  • Synthesis, Preparation and Analysis fo Uremic Toxins (2009), -
    Handelman, G.J. (Principal)
  • Measurement of C-reactive Protein and Interleukin-6 in Plasma Samples from Patien (2007), Grant -
    Handelman, G.J. (Principal)
  • Analyze 120 Samples a-tocopherol and g-tocopherol (2006), Grant -
    Handelman, G.J. (Principal)