Kelsey Mangano

Expertise

Nutritional Epidemiology; Nutritional Sciences; Clinical Trials; Gut Microbiome; Musculoskeletal Aging

Research Interests

Prof. Mangano's research interests include exploring the relation between diet, gastrointestinal health and musculoskeletal outcomes. Current laboratory projects aim to elucidate:

1. the effects of fermented dairy on the gut microbiome and bone;
2. the impact of food additives on gut homeostasis and the gut microbiome; and
3. the complex interactions of diet, the gut microbiome and cardiometabolic health.

Future research directions include developing dietary interventions to improve gut homeostasis and overall health.

Education

• Ph D: Nutritional Sciences, (2012), University of Connecticut
• MS: Allied Health Sciences, (2009), University of Connecticut
• BS: Dietetics, (2007), University of Connecticut

Biosketch

Kelsey M. Mangano, Ph.D., R.D., is Associate Professor of Nutritional Sciences in the Department of Biomedical and Nutritional Sciences at UMass Lowell. She is a member of the Center for Population Health and the UMass Movement Center at UMass Lowell. Professor Mangano also holds an Adjunct Faculty appointment at the Marcus Institute, Hebrew SeniorLife, Harvard Medical School affiliate. Please see CV for further background.

Selected Awards and Honors

• Teaching Excellence (2017), Biomedical and Nutritional Sciences
• 2016 Future Leader Award Finalist (2015), Scholarship/Research - International Life Studies Institute of Northern America
• Emerging Leaders in Nutrition Science Poster Competition Nominee (2015), Scholarship/Research - American Society of Nutrition
• Postdoctoral Research Award Competition Nominee (2015), Scholarship/Research - DuPont Nutrition & Health American Society of Nutrition
• Aging and Chronic Disease Research Interest Section Poster Competition Award Winner (2014), Scholarship/Research - American Society of Nutrition
• U.S. Bone and Joint Initiative Young Investigators program (2014), Scholarship/Research - U.S. Bone and Joint Initiative
• Seventh Fellows Forum on Metabolic Bone Diseases (2013), Scholarship/Research - American Society for Bone and Mineral Research
• Young Investigator Award (2013), Scholarship/Research - American Society for Bone and Mineral Research
• American Dietetic Association Outstanding Dietetic Student (2007), Scholarship/Research - American Dietetic Association
• G. Jane Hartman Scholarship Recipient (2006), Scholarship/Research - American Dietetic Association

Selected Publications

• Mangano K.M., Noel, S.E., Lai, C.Q., Christensen, J.J., Ordovas, J.M., Dawson-Hughes, B., Tucker, K.L.; Laurence D. Parnell, PhD. (2021). Diet-derived fruit and vegetable metabolites suggest sex-specific mechanisms conferring protection against osteoporosis in humans. Bone. 144:115780. DOI: 10.1016/j.bone.2020.115780. Epub 2020 Dec 2.
• Putra C., Konow N., Gage M., York C.G., Mangano K.M. (2021). Protein Source and Muscle Health in Older Adults: A Literature Review. Nutrients 2021, 13(3), 743; DOI: https://doi.org/10.3390/nu13030743
• Riseberg E., Lopez-Cepero A., Mangano K.M., Tucker K.L., Mattei J. (2021). Specific dietary protein sources are associated with cardiometabolic risk factors in the Boston Puerto Rican Health Study. Academy of Nutrition and Dietetics. In Press.
• Mangano K.M., Noel S.E., Zhang X., Tucker K.L. (2021). Sufficient plasma vitamin C is related to greater bone mineral density among postmenopausal women from the Boston Puerto Rican Health Study. J Nutr. In Press. 
• Maldonado-Contreras A.L., Noel S.E., Ward D.V., Velez M., Mangano K.M. (2020). Associations between diet, the gut microbiome and short chain fatty acid production among older Caribbean Latino adults are ameliorated by laxative use. J Acad Nutr Diet. 120(12):2047-2060.e6. DOI: 10.1016/j.jand.2020.04.018. Epub 2020 Aug 12.
• Kronrod, A., Hammar, M.E., Lee, J., Thind, H.K., Mangano, K.M. (2020). Linguistic Delight Promotes Eating Right: Figurative Language Increases Perceived Enjoyment and Encourages Healthier Food Choices. Health Communication,August.
• Feldeisen, S.N., Mangano, K., Mattei, J., Griffith, J.L., Dawson-Hughes, B., Bigornia, S., Tucker, K.L. (2020). Dietary Approaches to Stop Hypertension, Mediterranean, and Alternative Healthy Eating indices are associated with bone health among Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study. The American journal of clinical nutrition,111(6) 1267-1277.
• Quinn, B., ElGhaziri, M., Mangano, K., Thind, H.K. (2019). Toward Total Student Health: A Qualitative Pilot Study. Journal of American College Health,67(5) 391-396.
• Noel, S.E., Arevalo, S.P., Mena, N.Z., Mangano, K., Velez, M., Dawson-Hughes, B., Tucker, K.L. (2019). Knowledge, Attitudes, Beliefs, and Health Behaviors of Bone Health among Caribbean Hispanic/Latino Adults. Archives of osteoporosis,14(1) 14.
• Mangano, K., Noel, S.E., Sahni, S., Tucker, K.L. (2019). Higher Dairy Intakes Are Associated with Higher Bone Mineral Density among Adults with Sufficient Vitamin D Status: Results from the Boston Puerto Rican Osteoporosis Study. The Journal of nutrition,149(1) 139-148.
• Noel, S.E., Mangano, K., Griffith, J.L., Wright, N.C., Dawson-Hughes, B., Tucker, K.L. (2017). Prevalence of osteoporosis and low bone mass among Puerto Rican older adults. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
• Mangano, K., Sahni, S., Kiel, D.P., Tucker, K.L., Dufour, A.B., Hannan, M.T. (2017). Reply to G Bahat and MA Karan. (106:2 pp. 703). The American journal of clinical nutrition
• Sahni, S., Mangano, K., Kiel, D.P., Tucker, K.L., Hannan, M.T. (2017). Dairy Intake Is Protective against Bone Loss in Older Vitamin D Supplement Users: The Framingham Study. The Journal of nutrition,147(4) 645-652.
• Mangano, K., Sahni, S., Kiel, D.P., Tucker, K.L., Dufour, A.B., Hannan, M.T. (2017). Dietary protein is associated with musculoskeletal health independently of dietary pattern: the Framingham Third Generation Study. The American journal of clinical nutrition,105(3) 714-722.
• Mangano, K., Tucker, K. (2016). Bone health and vegan diets. © Elsevier
• McLean, R.R., Mangano, K., Hannan, M.T., Kiel, D.P., Sahni, S. (2016). Dietary Protein Intake Is Protective Against Loss of Grip Strength Among Older Adults in the Framingham Offspring Cohort. Journals of Gerontology Series A: Biological Sciences & Medical Sciences!!!,71(3) 356 - 361.
• MT, H., Sahni, S., Mangano, K. (2016). Evidence for a link between dietary protein and bone and muscle health in adults (8: pp. 51-60). © Springer International Publishing
• Mangano, K., Kenny, A. (2016). The Role of Diet and Nutritional Status in Recovery from Hip Fracture in the Elderly. Current Nutrition Reports,5(2) 113.
• McLean, R.R., Mangano, K., Hannan, M.T., Kiel, D.P., Sahni, S. (2015). Dietary Protein Intake Is Protective Against Loss of Grip Strength Among Older Adults in the Framingham Offspring Cohort. The Journals Of Gerontology.Series A, Biological Sciences And Medical Sciences.
• Mangano, K., Sahni, S., Kiel, D.P., Tucker, K.L., Dufour, A.B., Hannan, M.T. (2015). Bone Mineral Density and Protein-Derived Food Clusters from the Framingham Offspring Study. Journal Of The Academy Of Nutrition And Dietetics,115(10) 1605-1613.e1.
• Sahni, S., Mangano, K., McLean, R.R., Hannan, M.T., Kiel, D.P. (2015). Dietary Approaches for Bone Health: Lessons from the Framingham Osteoporosis Study. Current Osteoporosis Reports,13(4) 245-255.
• Sahni, S., Mangano, K., Hannan, M.T., Kiel, D.P., McLean, R.R. (2015). Higher Protein Intake Is Associated with Higher Lean Mass and Quadriceps Muscle Strength in Adult Men and Women. The Journal of nutrition,145(7) 1569-1575.
• Hannan, M.T., Mangano, K., Sahni, S. (2015). Do nutrients influence bone health? A commentary on new findings in the field. Journal Of Bone And Mineral Research: The Official Journal Of The American Society For Bone And Mineral Research,30(6) 967-969.
• Kerstetter, J.E., Bihuniak, J.D., Brindisi, J., Sullivan, R.R., Mangano, K., Larocque, S., Kotler, B.M., Simpson, C.A., Cusano, A.M., Gaffney-Stomberg, E., Kleppinger, A., Reynolds, J., Dziura, J., Kenny, A.M., Insogna, K.L. (2015). The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults. The Journal of clinical endocrinology and metabolism,100(6) 2214-2222.
• Sahni, S., Mangano, K., Tucker, K.L., Kiel, D.P., Casey, V.A., Hannan, M.T. (2014). Protective association of milk intake on the risk of hip fracture: results from the Framingham Original Cohort. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,29(8) 1756-62.
• Gregorio, L., Brindisi, J., Kleppinger, A., Sullivan, R., Mangano, K.M., Bihuniak, J., Kenny, A.M., Kerstetter, J., Insogn, K. (2014). Adequate dietary protein is associated with better physical performance among post-menopausal women 60–90 years. The journal of nutrition, health & aging,18(2) 155-160.
• Mangano, K., Kerstetter, J.E., Kenny, A.M., Insogna, K., Walsh, S. (2014). An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey years 2005–2008. Osteoporosis International,25(3) 1033-1041.
• Mangano, K., Walsh, S.J., Kenny, A.M., Insogna, K.L., Kerstetter, J.E. (2014). Dietary acid load is associated with lower bone mineral density in men with low intake of dietary calcium. Journal of Bone and Mineral Research,29(2) 500-506.
• Mangano, K., Sahni, S., Kerstetter, J.E. (2014). Dietary protein is beneficial to bone health under conditions of adequate calcium intake: an update on clinical research. Current opinion in clinical nutrition and metabolic care,17(1) 69-74.
• Mangano, K., Sahni, S., Kerstetter, J.E., Kenny, A.M., Hannan, M.T. (2013). Polyunsaturated fatty acids and their relation with bone and muscle health in adults. Current osteoporosis reports,11(3) 203–212.
• Mangano, K., Anne, K.M., Weiss, H.H., J, W.S., R, A., R, B., R, L., P, F., A, K., L, P., K, P., J, K.E. (2013). Soy proteins and isoflavones impact on serum lipids and inflammatory markers in older women. Nutrition research,33(12) 1026–1033.
• Mangano, K., Hutchins-Wiese, H.L., Kenny, A.M., Walsh, S.J., Abourizk, R.H., Bruno, R.S., Lipcius, R., Fall, P., Kleppinger, A., Kenyon-Pesce, L., others, . (2013). Soy proteins and isoflavones reduce interleukin-6 but not serum lipids in older women: a randomized controlled trial. Nutrition research,33(12) 1026–1033.
• Mangano, K., Walsh, S.J., Insogna, K.L., Kenny, A.M., Kerstetter, J.E. (2011). Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from the National Health and Nutrition Examination Survey 2003-2006. Journal of the American Dietetic Association,111(5) 687–695.
• Kenny, A.M., Mangano, K., Abourizk, R.H., Bruno, R.S., Anamani, D.E., Kleppinger, A., Walsh, S.J., Prestwood, K.M., Kerstetter, J.E. (2009). Soy proteins and isoflavones affect bone mineral density in older women: a randomized controlled trial. The American journal of clinical nutrition, ajcn–27600.

Selected Presentations

• Putra C., Bello D., Kelleher S.L., Tucker K.L., Mangano K.M. Dietary Intake and Fecal Excretion of Titanium Dioxide in U.S. Adults from Lowell, Massachusetts. American Society for Nutrition, Nutrition 2021 annual scientific meeting (Virtual, 2021) poster.
• McGrail L., Noel S.E., Maldonado-Contreras A., Mangano K.M. The Effect of Daily Yogurt Supplementation on Inflammation and Bone Biomarkers. American Society for Nutrition, Nutrition 2021 annual scientific meeting (Virtual, 2021)poster.
• Mangano K.M., Noel S.E., Zhang X., Tucker K.L. Prospective Relations Between the Dietary Approaches to Stop Hypertension (DASH) and Mediterranean Diet (MeDS) Scores and Self-Report Arthritis Among Puerto Rican Adults. American Society for Nutrition Annual Scientific Meeting (Seattle, WA, 2020) poster presentation.
• Mangano K.M., Noel S.E., Dawson-Hughes B., Tucker K.L. Plasma Vitamin C Sufficiency is Related to Higher Bone Mineral Density: The Boston Puerto Rican Osteoporosis Study. American Society for Bone and Mineral Research Annual Scientific Meeting (Virtual, 2020) poster presentation.
• Metabolomic signatures of high fruit and vegetable intake and reduced prevalence of osteoporosis: The Boston Puerto Rican Osteoporosis Study - American Society for Bone and Mineral Research Annual Meeting, October 2018 - Montreal, CA
• Dietary Quality Indices are Related to Bone Health among Puerto Rican Adults. - Nutrition 2018 Annual Meeting, June 2018 - Boston, MA
• Dairy Based Desserts are Negatively Associated with Bone Mineral Density among Puerto Rican Adults, 2016 - San Diego, CA
• Dietary protein food sources, dietary patterns and bone health, 2016 - The International Dairy Nutrition Symposium, Utrecht University Utrecht, Netherlands
• Dietary protein food pattern is associated with lean mass, but not strength among protein replete adults, 2015 - Montreal, Canada
• Dietary Protein Pattern is Not Associated with Muscle Mass or Strength Among Protein Replete Adults, 2015 - Boston
• Nutrition and bone health: a story beyond calcium, 2015 - Massachusetts Dietetics in Health Care Communities Association, Westborough, MA
• The Mediterranean Diet and our Health , 2015 - The International Studies Institute Palazzo Rucellai, Florence Italy
• Dietary protein intake is important for bone health in an aging population, 2014 - Diary Council of Northern Ireland Belfast, Ireland
• Dietary protein patterns are not associated with lean mass or strength among adults from the Framingham 3rd Generation Cohort, 2014 - Houston
• Individual protein food sources are associated with greater bone mineral density among men and women from the Framingham Offspring Study, 2014 - San Diego
• Nutrition and bone health: a story beyond calcium, 2014 - Massachusetts Dietetic Association Middleton, MA
• The Effect of Long Term Whey Protein Supplementation on Bone Mineral Density and Body Composition in Older Adults: A Randomized, Double-Blind, Controlled Trial , 2014 - Chicago
• The Mediterranean Diet and our Health , 2014 - The International Studies Institute Palazzo Rucellai, Florence Italy
• Dietary intake is not associated with quadriceps muscle strength in adults : The Framingham Offspring Study, 2013 - Baltimore
• Intakes of total and plant protein are associated with greater muscle strength: The Framingham Osteoporosis Study., 2013 - American Society of Nutrition, Experimental Biology Annual Meeting (Boston)
• Protein intake is protective against grip strength loss in adults: The Framingham Osteoporosis Study, 2013 - Baltimore; ADA
• Sweet-baked products, but not whole or refined grains, are negatively associated with bone mineral density (BMD): the Framingham Offspring Cohort., 2013 - American Society of Nutrition, Experimental Biology Annual Meeting (Boston)
• The Mediterranean Diet and our Health , 2012 - The International Studies Institute Palazzo Rucellai, Florence Italy
• Maintenance of Adequate Calcium Intake in Adults: Lessons from the National Health and Nutrition Examination Survey, 2011 - University of Connecticut Health Center Clinical Research Center Framingham, CT
• Nutritional Supplements-Which Ones Should you Consider Adding to Your Diet?, 2011 - NBC30-Connecticut News
• Inside a Dietitians Cupboard, 2010 - NBC30-Connecticut News

Selected Contracts, Fellowships, Grants and Sponsored Research

• Mangano, K.M. (Principal), Tucker, K. (Co-Investigator), Mattei, J. (Co-Investigator, HSPH). Longitudinal associations between dairy foods and biomarkers with cardiometabolic outcomes among adults from the Boston Puerto Rican Osteoporosis Study (2021-2023), Grant - National Dairy Council
• Mangano, K.M. (Principal), Tucker, K. (Co-Investigator), Bello, D. (Co-Investigator), Kelleher, S. (Co-Investigator). Dietary titanium dioxide exposure and gut health among adults (2021-2023), Grant - USDA, A1343
• Mangano, K.M. (Principal), Noel, S. (Principal), Tucker, K. (Co-Investigator), Falcon, L. (Co-Investigator), Rajabiun, S. (Co-Investigator). The impact of the COVID-19 pandemic on psychosocial health and other social factors in a longitudinal cohort of Puerto Rican adults living on the US mainland (2020-2021), Grant - University of Massachusetts, Lowell Internal Seed Grant COVID-19 Response.
• Improve musculoskeletal Health especially among the elderly (2018), Grant - IDEA Inter-Disciplinary Exchange & Advancement Initiative
  Lewis, E.S., Gage, M., Nugent, M.A., Mangano, K., Konow, N., Scribner-Maclean, M.
• Identifying mechanisms underpinning the impact of daily yogurt supplementation on the gut microbiome; inflammation and bone biomarker (2017), Grant - International Osteoporosis Foundation, American Society for Nutrition, Dannone
  Mangano, K.M., Noel, S.E., Maldonado-Contreras, A.
• Bone Microarchitecture, Diabetes and Change in Bone Mineral Density in Puerto Rican Adults (2018), Grant - NATIONAL INSTITUTES OF HEALTH
  Mangano, K.M. (Co-Investigator), Tucker, K.L. (Principal), Noel, S.E. (Co-Investigator)
• The impact of the COVID-19 pandemic on psychosocial health and other social factors in a longitudinal cohort of Puerto Rican adults living on the US mainland (2020), Grant -
  Mangano, K.M., Feldeisen, S.N., Rajabiun, S., Falcón, L.M., Tucker, K.L.
• It's Fun to Run – or is it Just a Pun? Detecting Signs of Enjoyment with Physical Activity and Food Choices through Computational Analysis of Figurative Language in Online Communication (2018), Grant - UMass Lowell
  Kronrod, A. (Co-Principal), Rumshisky, A. (Co-Principal), Thind, H.K. (Co-Investigator), Mangano, K. (Co-Investigator)
• Using a Pun to a Make Healthy Life Run: Exploring the Use of Figurative Language in Encouraging Healthier Behavior (2018), Grant - Manning School of Business and the Zuckerberg College of Health Sciences
  Kronrod, A. (Principal), Thind, H.K. (Co-Principal), Mangano, K. (Co-Principal)
• Identifying mechanisms underpinning the impact of daily yogurt supplementation on the gut microbiome, inflammation and bone biomarkers (2017), Grant - Yogurt in Nutrition Research Initiative
  Mangano, K. (Principal)
• UMass Lowell towards Total Student Health (2016), Grant - Zuckerberg College of Health Sciences
  Quinn, B. (Co-Principal), Thind, H.K. (Principal), Mangano, K. (Co-Principal), ElGhaziri, M. (Co-Principal)
• Aging from the inside out (2016), Grant - University of Massachusetts, Lowell Internal Seed Grant
  Mangano, K. (Principal), Noel, S.E. (Co-Principal), (Supporting)
• Protein Food Clusters and Measures of Bone Mineral Density and Muscle Strength NIA-T32 (2013), Grant - BIDMDC/Harvard Translational Research in Aging Training Program
  Mangano, K., Lipsitz, L.
• Protein Food Clusters and Measures of Bone Mineral Density and Muscle Strength (2013), Sponsored Research - Academy of Nutrition and Dietetics, Healthy Aging DPG
  Mangano, K.