The Massachusetts Biomanufacturing Center (MBMC) at UMass Lowell addresses industry-wide concerns in a multidisciplinary manner to develop procedures that lead to validated, cGMP-compliant manufacturing processes.

Continuous Chromatography for Oligos and Peptides Workshop

November 10-11, 2022

Two-day hands-on workshop that introduces twin-column continuous chromatography using MCSGP (Multicolumn Countercurrent Solvent Gradient Purification).

The workshop includes presentations and lab workshops for oligo or peptide purification.

  • When: Thursday November 10 and Friday November 11, 2022
  • Where: Perry Hall, 197 Riverside St., Lowell, MA 01854
  • Cost: $1500, Registration Deadline: Nov. 9 at noon.

For more information or questions please email: Pamela_Donoghue@uml.edu or lpankoe@ymcpt.com.

Agenda - Day 1: Thursday, Nov. 10, 2022

9 - 10:30 a.m. - Introduction to Continuous Chromatography Presentation:

  • Setup and System Qualification of CUBE instrument

10:30 - 10:45 a.m. - Coffee Break

10:45 a.m. - 12:30 p.m. - Setting up Continuous Chromatography Lab Workshop:

  • Introduction to the Contichrom CUBE systemand software
  • Designing and running batch and MCSGP methods

12:30 - 1:30 p.m. - Lunch Break

1:30 - 2:30 p.m. - Monitoring of Continuous Chromatography Lab Workshop:

  • Interpretation of online MCSGP data
  • Sampling of MCSGP

2:30 - 4:30 p.m. - Scale-up of Continuous Chromatography Presentation:

  • Control of continuous chromatography
  • Scale-up
  • Regulatory aspects

4:30 - 7:30 p.m. - Group Dinner


Agenda - Day 2: Friday, Nov. 11, 2022

9-10 a.m. - Evaluation of Continuous Chromatography (Lab) Lab Workshop:

  • ChromIQ Evaluation Center

10 - 10:15 a.m. - Coffee Break

10:15 - 11:15 a.m. - Evaluation of Continuous Chromatography Presentation:

  • Performance metrics
  • Economic evaluation

11:15 – Noon - Modeling of Continuous Chromatography

Noon – 1 p.m. - Lunch Break

1-2 p.m. - Introduction to the N-Rich process Presentation

2- 2:30 p.m. - Wrap-Up Presentation:

  • Discussion of results
  • Question and Answer (Q&A)

2:30 - 4:30 p.m. - Tour of YMC America Insight Center

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