38.501 Physiological Dynamics

Physiological Dynamics

Course Details
Min Credits 3
Max Credits 3
Course ID 36396
Status Active

This course will provide intermediate to advanced coverage of physiological dynamics. A myriad of complex dynamics underlie health and disease and represent highly integrated regulatory systems with cycles, oscillations and feedbacks across time and scale. Physiological Dynamics will teach students basic tools for analyzing the dynamics of the physiological systems; and to identify normal dynamics and relate altered dynamics to disease. The course will focus on the interpretation of physiological dynamics in understanding healthy response to exercise, stress, fatigue and disease. Topics will include physiological origins and implications of: the normal electrocardiogram (ECG); common ECG abnormalities, temporal variations in the physiological system (heart rate variability, blood pressure variability, blood flow, pulse transit time); and multi level relationships between components of physiological regulation. A common theme will be the added clinical information associated with understanding the temporal and spatial dynamics of the physiological systems. Temporal dynamics will include both short cycle dynamics (days to weeks) as well as longer range cycles (i.e. the life cycle). Spatial dynamics will include multi level - bidirectional interactions that emerge through cell, organ, system, organism, and environmental scales. There will be an emphasis on the important recurrent feedback loops between human and environment in long-term health trajectories and transitions from health to disease and from acute disturbances to chronic conditions. .